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Lactobacillus rhamnosus GG and HbA1c in middle age and older adults without type 2 diabetes mellitus: A preliminary randomized study.

  • 2020-09
  • Diabetes & Metabolic Syndrome: Clinical Research & Reviews 14(5)
    • Victoria Sanborn
    • M. Azcarate-Peril
    • J. Gunstad

Abstract

Background and aims: Probiotic supplementation improves glycemic control in persons with diabetes and the current study examined whether these benefits extend to healthy individuals.

Methods: The current study was a 90-day placebo-controlled, double-blind, randomized clinical trial of Lactobacillus rhamnosus GG in healthy middle-aged and older adults. Fasting blood glucose and HbA1c were quantified at baseline and follow up.

Results: ANCOVA controlling for baseline values showed group differences in follow up HbA1c [F (1,90) = 8.44, p = 0.005]; HbA1c values increased in the placebo group, though remained stable in the probiotic group.

Conclusions: If replicated, Lactobacillus rhamnosus GG may protect against changes in glycemic control.

Keywords: Diabetes mellitus; Gut microbiota; Lactobacillus; Probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosus GGRegulated Blood Glucose LevelsBeneficial
Moderate
Lactobacillus rhamnosus IMC 501Regulated Blood Glucose LevelsBeneficial
Moderate
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