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Lactobacillus rhamnosus GG can protect malnourished children.

  • 2019-04-19
  • Beneficial Microbes 10(3)
    • S. Kara
    • B. Volkan
    • I. Erten

Abstract

Malnutrition affects virtually all organ systems, and malnourished children are more prone to infections. These children have dysbiosis, but probiotics can restore the disrupted gut microbiome. We investigated the protective effects of Lactobacillus rhamnosus GG in malnourished children in terms of incidence of infection, and anthropometric and metabolic parameters. 50 intervention and 50 control patients, aged 6 months to 5 years, with body weight and height below -2 SD, were randomly and prospectively recruited. The controls received a calorie and protein-appropriate diet for 3 months, while the study group additionally received approximately 109 L. rhamnosus GG for 3 months. Infection episodes and nutritional status were compared between the groups. 38 intervention, 33 control patients completed the study and the two groups were similar at baseline. The study group had fewer upper respiratory tract infections and gastroenteritis episodes at each month and at the end of the study. Children in the study group experienced fewer total upper respiratory infections and urinary tract infections. Hospitalisation was more frequent in the control group during the third month and at the end of the study. Total infection numbers were higher in the control group at each month and at the end of the study (P<0.001 for each). Increments in body mass index (BMI) and BMI Z-scores were more pronounced in the study group (P=0.008 and P=0.02, respectively). Daily prophylactic use of L. rhamnosus GG at 109 bacteria in malnourished children prevents most infections and improves nutritional status when used together with appropriate diet.

Keywords: body mass index; children; infection; malnutrition; prealbumin.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus rhamnosusImproved Body Mass IndexBeneficial
Moderate
Lactobacillus rhamnosusReduced Hospitalization RateBeneficial
Large
Lactobacillus rhamnosusReduced Incidence of Upper Respiratory Tract InfectionsBeneficial
Large
Lactobacillus rhamnosusReduced Urinary Tract Infection IncidenceBeneficial
Large
Lactobacillus rhamnosus DSM33560Improved Body Mass IndexBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Improved Nutritional StatusBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Reduced Hospitalization RateBeneficial
Large
Lactobacillus rhamnosus DSM33560Reduced Upper Respiratory InfectionsBeneficial
Large
Lactobacillus rhamnosus GGImproved Nutritional StatusBeneficial
Moderate
Lactobacillus rhamnosus GGIncreased Body Mass IndexBeneficial
Moderate
Lactobacillus rhamnosus GGReduced Hospitalization RateBeneficial
Large
Lactobacillus rhamnosus GGReduced Incidence of GastroenteritisBeneficial
Large
Lactobacillus rhamnosus GGReduced Infection RateBeneficial
Large
Lactobacillus rhamnosus GGReduced Upper Respiratory InfectionsBeneficial
Large
Lactobacillus rhamnosus GGReduced Urinary Tract Infection IncidenceBeneficial
Large
Lactobacillus rhamnosus LBV 96Improved Body Mass IndexBeneficial
Moderate
Lactobacillus rhamnosus LBV 96Improved Nutritional StatusBeneficial
Moderate
Lactobacillus rhamnosus LBV 96Reduced Hospitalization RateBeneficial
Large
Lactobacillus rhamnosus LBV 96Reduced Incidence of GastroenteritisBeneficial
Large
Lactobacillus rhamnosus LBV 96Reduced Infection RateBeneficial
Large
Lactobacillus rhamnosus LBV 96Reduced Upper Respiratory InfectionsBeneficial
Large
Lactobacillus rhamnosus LBV 96Reduced Urinary Tract Infection IncidenceBeneficial
Large
Lactobacillus rhamnosus LBV96Improved Body Mass IndexBeneficial
Moderate
Lactobacillus rhamnosus LBV96Improved Nutritional StatusBeneficial
Moderate
Lactobacillus rhamnosus LBV96Reduced Human InfectionsBeneficial
Large
Lactobacillus rhamnosus LBV96Reduced Infection IncidenceBeneficial
Large
Lactobacillus rhamnosus Lr-32Improved Nutritional StatusBeneficial
Moderate
Lactobacillus rhamnosus Lr-32Increased Body Mass IndexBeneficial
Moderate
Lactobacillus rhamnosus Lr-32Reduced Hospitalization RateBeneficial
Large
Lactobacillus rhamnosus Lr-32Reduced Human InfectionsBeneficial
Large
Lactobacillus rhamnosus Lr-32Reduced Incidence of GastroenteritisBeneficial
Large
Lactobacillus rhamnosus Lr-32Reduced Incidence of Upper Respiratory Tract InfectionsBeneficial
Large
Lactobacillus rhamnosus Lr-32Reduced Urinary Tract Infection IncidenceBeneficial
Large
Lactobacillus rhamnosus lysate powderImproved Nutritional StatusBeneficial
Moderate
Lactobacillus rhamnosus lysate powderReduced Hospitalization RateBeneficial
Large
Lactobacillus rhamnosus lysate powderReduced Pathogen InfectionBeneficial
Large
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