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Lactobacillus rhamnosus GG in adenoid tissue: Double-blind, placebo-controlled, randomized clinical trial.

  • 2015-03-26
  • Acta oto-laryngologica 135(8)
    • Elisa Swanljung
    • Laura Tapiovaara
    • Liisa Lehtoranta
    • Harri Mäkivuokko
    • Merja Roivainen
    • Riitta Korpela
    • Anne Pitkäranta

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 40
Population
40 children aged 1-5 years about to undergo adenotomy due to recurrent acute/secretory otitis media, chronic rhinitis, or recurrent sinusitis
Methods
3-week daily consumption of L.GG (n = 20) or placebo (n = 20); strain-specific real-time PCR used to detect RV, EV, and L.GG in adenoid tissue
Blinding
Double-blind
Duration
3-week
Funding
Unclear

Conclusion

Lactobacillus rhamnosus GG (L.GG) was present in all adenoids of children receiving the L. GG product. However, since L.GG was also found from the placebo group, one cannot confirm its effect on the occurrence of rhinovirus (RV) or enterovirus (EV).

Objectives

The present study was conducted to determine whether a 3-week oral consumption of L.GG would lead to presence of the probiotic in adenoid tissue. Furthermore, nasopharyngeal RV and EV findings and symptom data were investigated.

Method

The tissue samples were collected from 40 children aged 1-5 years about to undergo adenotomy due to recurrent acute/secretory otitis media, chronic rhinitis, or recurrent sinusitis after a 3-week daily consumption of L.GG (n = 20) or placebo (n = 20). Strain-specific real-time PCR was used to detect RV, EV, and L.GG in adenoid tissue.

Results

L.GG was recovered in the adenoid sample in 100% of children in the L.GG group and in 76% in the placebo group (p = 0.07). Both RV and EV were found in 31% of children in the L.GG group and in 18% of children in the placebo group (p = 0.67). The majority of the positive samples were positive for both RV and EV. Study diaries showed no differences in symptoms between the groups.

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