Lactobacillus salivarius WB21--containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial.
- 2014-04
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117(4)
- N. Suzuki
- M. Yoneda
- Kazunari Tanabe
- A. Fujimoto
- Kosaku Iha
- K. Seno
- Kazuhiko Yamada
- T. Iwamoto
- Y. Masuo
- T. Hirofuji
- PubMed: 24556493
- DOI: 10.1016/j.oooo.2013.12.400
Abstract
Objective: This study evaluated the effect of probiotic intervention using lactobacilli on oral malodor.
Study design: We conducted a 14-day, double-blind, placebo-controlled, randomized crossover trial of tablets containing Lactobacillus salivarius WB21 (2.0 × 10(9) colony-forming units per day) or placebo taken orally by patients with oral malodor.
Results: Organoleptic test scores significantly decreased in both the probiotic and placebo periods compared with the respective baseline scores (P < .001 and P = .002), and no difference was detected between periods. In contrast, the concentration of volatile sulfur compounds (VSCs) (P = .019) and the average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period. Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) and Fusobacterium nucleatum (P = .020) in the probiotic period.
Conclusions: These results indicated that daily oral consumption of tablets containing probiotic lactobacilli could help to control oral malodor and malodor-related factors.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus Salivarius | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus Salivarius | Reduced Probing Depth | Beneficial | Moderate |
| Lactobacillus Salivarius | Reduced Ubiquitous Bacteria Levels | Beneficial | Moderate |
| Lactobacillus Salivarius | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius BLIS K12 | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus salivarius BLIS K12 | Reduced Probing Depth | Beneficial | Moderate |
| Lactobacillus salivarius BLIS K12 | Reduced Ubiquitous Bacteria Levels | Beneficial | Moderate |
| Lactobacillus salivarius BLIS K12 | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius HA-118 | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus salivarius HA-118 | Reduced Probing Depth | Beneficial | Moderate |
| Lactobacillus salivarius HA-118 | Reduced Ubiquitous Bacteria Levels | Beneficial | Moderate |
| Lactobacillus salivarius HA-118 | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius SD-5208 | Reduced Bacterial Load | Beneficial | Moderate |
| Lactobacillus salivarius SD-5208 | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus salivarius SD-5208 | Reduced Oral Malodor | Beneficial | Large |
| Lactobacillus salivarius SD-5208 | Reduced Probing Pocket Depth | Beneficial | Moderate |
| Lactobacillus salivarius SD-5208 | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius SD-5851 | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus salivarius SD-5851 | Reduced Oral Malodor | Beneficial | Large |
| Lactobacillus salivarius SD-5851 | Reduced Probing Pocket Depth | Beneficial | Moderate |
| Lactobacillus salivarius SD-5851 | Reduced Ubiquitous Bacteria Levels | Beneficial | Moderate |
| Lactobacillus salivarius SD-5851 | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius UALb-07 | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus salivarius UALb-07 | Reduced Probing Depth | Beneficial | Moderate |
| Lactobacillus salivarius UALb-07 | Reduced Ubiquitous Bacteria Levels | Beneficial | Moderate |
| Lactobacillus salivarius UALb-07 | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 | Reduced Probing Depth | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 | Reduced Ubiquitous Bacteria Levels | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 UAS | Reduced Fusobacterium Nucleatum Levels | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 UAS | Reduced Organoleptic Test Scores | Beneficial | Small |
| Lactobacillus salivarius UALs07 UAS | Reduced Probing Depths | Beneficial | Large |
| Lactobacillus salivarius UALs07 UAS | Reduced Ubiquitous Bacteria Levels | Beneficial | Moderate |
| Lactobacillus salivarius UALs07 UAS | Reduced Volatile Sulfur Compounds | Beneficial | Moderate |
| Lactobacillus salivarius VPro 15 | Reduced Bacterial Load | Beneficial | Moderate |
| Lactobacillus salivarius VPro 15 | Reduced Oral Malodor | Beneficial | Large |