Lactobacillus salivarius WB21--containing tablets for the treatment of oral malodor: a double-blind, randomized, placebo-controlled crossover trial.
- 2014-04
- Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 117(4)
- N. Suzuki
- M. Yoneda
- Kazunari Tanabe
- A. Fujimoto
- Kosaku Iha
- K. Seno
- Kazuhiko Yamada
- T. Iwamoto
- Y. Masuo
- T. Hirofuji
- PubMed: 24556493
- DOI: 10.1016/j.oooo.2013.12.400
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Population
- Patients with oral malodor
- Methods
- Randomized Controlled Trial
Abstract
Objective: This study evaluated the effect of probiotic intervention using lactobacilli on oral malodor.
Study design: We conducted a 14-day, double-blind, placebo-controlled, randomized crossover trial of tablets containing Lactobacillus salivarius WB21 (2.0 × 10(9) colony-forming units per day) or placebo taken orally by patients with oral malodor.
Results: Organoleptic test scores significantly decreased in both the probiotic and placebo periods compared with the respective baseline scores (P < .001 and P = .002), and no difference was detected between periods. In contrast, the concentration of volatile sulfur compounds (VSCs) (P = .019) and the average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period. Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) and Fusobacterium nucleatum (P = .020) in the probiotic period.
Conclusions: These results indicated that daily oral consumption of tablets containing probiotic lactobacilli could help to control oral malodor and malodor-related factors.
Research Insights
Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) and Fusobacterium nucleatum (P = .020) in the probiotic period.
- Effect
- Beneficial
- Effect size
- Moderate
Bacterial quantitative analysis found significantly lower levels of ... Fusobacterium nucleatum (P = .020) in the probiotic period.
- Effect
- Beneficial
- Effect size
- Moderate
These results indicated that daily oral consumption of tablets containing probiotic lactobacilli could help to control oral malodor and malodor-related factors.
- Effect
- Beneficial
- Effect size
- Large
average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period
- Effect
- Beneficial
- Effect size
- Moderate
Bacterial quantitative analysis found significantly lower levels of ... Fusobacterium nucleatum (P = .020) in the probiotic period.
- Effect
- Beneficial
- Effect size
- Moderate
In contrast, the concentration of volatile sulfur compounds (VSCs) (P = .019) and the average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period.
- Effect
- Beneficial
- Effect size
- Moderate
Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) in the probiotic period.
- Effect
- Beneficial
- Effect size
- Moderate
Bacterial quantitative analysis found significantly lower levels of ... Fusobacterium nucleatum (P = .020) in the probiotic period.
- Effect
- Beneficial
- Effect size
- Moderate
In contrast, the concentration of volatile sulfur compounds (VSCs) (P = .019) and the average probing pocket depth (P = .001) decreased significantly in the probiotic period compared with the placebo period.
- Effect
- Beneficial
- Effect size
- Moderate
Bacterial quantitative analysis found significantly lower levels of ubiquitous bacteria (P = .003) in the probiotic period.
- Effect
- Beneficial
- Effect size
- Moderate