Microbiome, Potential Therapeutic Agents: New Players of Obesity Treatment.

2025-04-24
Journal of microbiology and biotechnology 35

PubMed: 40295195
DOI: 10.4014/jmb.2501.01024

Study Design

Type: Review
Methods: This review evaluated the potential of the microbiome in treating obesity by targeting anti-adipogenesis and adipose tissue browning mechanisms.

Obesity is a global pandemic, and recent research has established a correlation between the microbiome and obesity, indicating potential treatment possibilities. This review evaluated the potential of the microbiome in treating obesity by targeting anti-adipogenesis and adipose tissue browning mechanisms. The microbiome impacts adipogenesis through lipogenesis and inflammation pathways and influences adipose tissue browning via the secretion of gut hormones and short-chain fatty acids. Understanding these mechanisms could pave the way for interventions targeting the gut microbiome to reduce obesity-related adiposity. While our understanding of the specific microbial species, metabolites, and signaling pathways involved in these processes is still limited, this review highlights the potential of microbiome-based therapies for obesity. Further research focused on identifying key microbial players and their mechanisms of action will be crucial for developing targeted and effective interventions. This will ultimately contribute to a more comprehensive understanding of obesity pathogenesis and facilitate the development of novel therapeutic strategies to combat this global health crisis.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Lactobacillus rhamnosus	—	Increased Adipose Browning	Beneficial	Small	View source This review evaluated the potential of the microbiome in treating obesity by targeting anti-adipogenesis and adipose tissue browning mechanisms.
Lactobacillus rhamnosus	—	Reduced Adipogenesis	Beneficial	Small	View source The microbiome impacts adipogenesis through lipogenesis and inflammation pathways and influences adipose tissue browning via the secretion of gut hormones and short-chain fatty acids.
Lactobacillus rhamnosus	—	Reduced Adiposity	Beneficial	Small	View source This review evaluated the potential of the microbiome in treating obesity by targeting anti-adipogenesis and adipose tissue browning mechanisms.