Microbiota-Based Intervention Alleviates High-Fat Diet Consequences Through Host-Microbe Environment Remodeling.
- 2025-04-22
- Nutrients 17(9)
- Lanlan Yi
- Zhipeng Li
- Hong Xu
- Dejia Shi
- Ying Huang
- Hongbin Pan
- Yanguang Zhao
- Hongye Zhao
- Minghua Yang
- Hongjiang Wei
- Sumei Zhao
- PubMed: 40362711
- DOI: 10.3390/nu17091402
Study Design
- Type
- Review
- Rigorous Journal
A high-fat diet leads to metabolic disturbances, which are important factors in the development of obesity. Gut microbial composition and diversity are altered by a high-fat diet. In general, a high-fat diet resulted in increased Firmicutes abundance and decreased alpha diversity. Bile acids (BAs) are involved in the digestion and absorption of fats in the small intestine and are also the metabolic substrates of microorganisms with bile salt hydrolase (BSH) activity. High-fat diets (HFDs) have been shown to alter gut microbiota composition and BA profiles in murine models. Similarly, probiotic supplementation reverses HFD-induced adverse effects. This review focuses on the energy composition characteristics of a high-fat diet and its effects on body weight, plasma lipid-related biochemical markers, changes in gut microbiome characteristics, and the important role of BAs. The regular mechanism by which a high-fat diet affects the intestinal microenvironment was attempted to be found.