Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction.

  • 2019
  • Bratislavske lekarske listy 120(12)
    • B Trebaticky
    • J Muchova
    • S Ziaran
    • P Bujdak
    • J Breza
    • Z Durackova

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 53
Population
53 patients with ED (32 with DM, 21 non-DM)
Methods
Randomised, blinded, placebo-controlled study; 3-month intervention with PYC or placebo, plus one month follow-up
Blinding
Double-blind
Duration
3 months
Funding
Unclear

Objectives

Erectile dysfunction (ED) is characterised as the inability to achieve or maintain an erection to complete sexual intercourse. ED may be considered as an early complication of diabetes mellitus (DM). The aim of this study was to assess the effect of registered food supplement, natural polyphenolic extract from the French maritime pine bark, Pycnogenol (PYC) on erectile function and lipid profile in ED patients.

Methods

53 patients with ED were divided into two groups (32 with DM, 21 non-DM) in randomised, blinded and placebo-controlled study. During 3-month intervention with PYC or placebo and one month after the end of the intervention patients were investigated for ED with validated questionnaire International Index of Erectile Function-5 (IIEF-5); lipid profile, glycaemia was analysed in each group.

Results

In a randomised, blinded and placebo-controlled study, we found that natural polyphenolic extract, Pycnogenol improved erectile function in DM group by 45 % compared to the NDM group, where the improvement was also significant, but only by 22 %. Total cholesterol, LDL-cholesterol and glucose level was lowered by PYC in patients with DM. Glucose level was not affected by PYC in non-DM. Placebo showed no effect on monitored parameters in both groups.

Conclusion

Administration of Pycnogenol leads in improvement of erectile function in patients with ED and diabetes (DM group) by 45 %, in NDM group by 22 %, in lowering of total-, LDL-cholesterol by 20 % and 21 % and glycaemia by 22 % in DM (Tab. 2, Fig. 2, Ref. 19).

Research Insights

  • Pine→Improved Erectile Function

    natural polyphenolic extract, Pycnogenol improved erectile function in DM group by 45 % compared to the NDM group, where the improvement was also significant, but only by 22 %.

    Effect
    Beneficial
    Effect size
    Large
  • Pine→Reduced Blood Cholesterol

    Total cholesterol, LDL-cholesterol and glucose level was lowered by PYC in patients with DM...lowering of total-, LDL-cholesterol by 20 % and 21 % and glycaemia by 22 % in DM

    Effect
    Beneficial
    Effect size
    Moderate
  • Pine→Reduced Blood Glucose Levels

    Total cholesterol, LDL-cholesterol and glucose level was lowered by PYC in patients with DM...glycaemia by 22 % in DM

    Effect
    Beneficial
    Effect size
    Moderate
  • Pine→Reduced LDL Cholesterol

    Total cholesterol, LDL-cholesterol and glucose level was lowered by PYC in patients with DM...lowering of total-, LDL-cholesterol by 20 % and 21 % and glycaemia by 22 % in DM

    Effect
    Beneficial
    Effect size
    Moderate
Back to top