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Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial.

  • 2019-08-14
  • Journal of orthopaedic surgery and research 14(1)
    • Chunhua Zhang
    • Sujuan Xue
    • Yong Wang
    • Dan Yu
    • Limei Hua
    • Chunhua Guo
    • Dawei Wang
    • Min Lei

Study Design

Type
Randomized Controlled Trial (RCT)
Population
264 senior patients with distal radius fracture
Methods
Double-blind, placebo-controlled clinical trial; oral placebo or LcS daily for 3 months after the fracture
Blinding
Double-blind
Duration
3 months
Funding
Unclear

Background

To evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture.

Methods

This clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month.

Results

Throughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period.

Conclusion

Oral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.

Research Insights

  • Lacticaseibacillus casei→Improved Hand Function

    MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo

    Effect
    Beneficial
    Effect size
    Small
  • Lacticaseibacillus casei→Improved Radial Deviation

    MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo

    Effect
    Beneficial
    Effect size
    Small
  • Lacticaseibacillus casei→Improved Radial Inclination

    MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo

    Effect
    Beneficial
    Effect size
    Small
  • Lacticaseibacillus casei→Improved Ulnar Deviation

    MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo

    Effect
    Beneficial
    Effect size
    Small
  • Lacticaseibacillus casei→Improved Ulnar Variance

    MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo

    Effect
    Beneficial
    Effect size
    Small
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