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Oral administration of Lactobacillus fermentum CRL1446 improves biomarkers of metabolic syndrome in mice fed a high-fat diet supplemented with wheat bran.

  • 2020
  • Food & Function 11(5)
    • R. Medina
    • Matías Russo
    • Antonela Marquez
    • Héctor M. Herrera
    • M. C. Abeijón-Mukdsi
    • L. Saavedra
    • E. Hebert
    • Paola Gauffin-Cano

Abstract

This work aimed to evaluate the effect of oral administration of probiotic Lactobacillus (L.) fermentum CRL1446, with feruloyl esterase (FE) activity, on metabolic biomarkers and intestinal microbiota of mice with high fat diet-induced Metabolic Syndrome (MS) and supplemented with wheat bran as a source of esterified ferulic acid. Six-week-old male Swiss albino mice developed the components of MS when fed with high fat diet supplemented with wheat bran (HFD + WB) for 14 weeks. Positive impact of L. fermentum CRL1446 administration on these animals was reflected in a decrease in body weight gain and adiposity index compared to the animals that did not receive the probiotic strain. In addition, a decrease in plasma leptin levels, improvement of inflammatory profile, reduction of fatty infiltration in hepatocytes and modification of lipid profile (increased HDL-cholesterol and decreased LDL-cholesterol and triglyceride levels) were observed. On the other hand, L. fermentum CRL1446 reduced fasting glucose and insulin levels, improving the HOMA index in mice with MS. Postprandial glucose levels were also reduced in the oral glucose tolerance test. Consumption of L. fermentum CRL1446 with HFD + WB (HFD + WB-Lf mice group) had a great impact on host metabolism, modulating intestinal microbiota, with an increase in Bacteroidetes and a decrease in Firmicutes abundance being observed. Increased intestinal FE activity, improved oxidative status and increased abundance of 3-hydroxyphenylpropionic acid and butyric acid concentration in colonic content, were also demonstrated in HFD + WB-Lf mice. Results obtained suggest that supplementation with L. fermentum CRL1446 enhances beneficial effects of a bran diet, attenuating the risk factors associated with MS.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus fermentumImproved Gut MicrobiotaBeneficial
Moderate
Lactobacillus fermentumImproved HOMA IndexBeneficial
Large
Lactobacillus fermentumImproved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentumImproved Oxidative StatusBeneficial
Moderate
Lactobacillus fermentumIncreased Butyrate LevelsBeneficial
Moderate
Lactobacillus fermentumIncreased Feruloyl Esterase Activity in the IntestineBeneficial
Moderate
Lactobacillus fermentumIncreased HDL Cholesterol LevelsBeneficial
Large
Lactobacillus fermentumReduced Adiposity IndexBeneficial
Large
Lactobacillus fermentumReduced Fasting Blood Sugar LevelsBeneficial
Large
Lactobacillus fermentumReduced Fatty Infiltration in HepatocytesBeneficial
Moderate
Lactobacillus fermentumReduced Insulin LevelsBeneficial
Large
Lactobacillus fermentumReduced LDL CholesterolBeneficial
Large
Lactobacillus fermentumReduced Plasma Leptin LevelsBeneficial
Large
Lactobacillus fermentumReduced Postprandial Glucose LevelsBeneficial
Large
Lactobacillus fermentum HA-179Improved HOMA IndexBeneficial
Large
Lactobacillus fermentum HA-179Improved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentum HA-179Improved Lipid ProfileBeneficial
Moderate
Lactobacillus fermentum HA-179Improved Oxidative StatusBeneficial
Moderate
Lactobacillus fermentum HA-179Increased Feruloyl Esterase Activity in the IntestineBeneficial
Moderate
Lactobacillus fermentum HA-179Modulated Gut MicrobiotaBeneficial
Moderate
Lactobacillus fermentum HA-179Reduced Fatty Infiltration in HepatocytesBeneficial
Moderate
Lactobacillus fermentum HA-179Reduced Plasma Leptin LevelsBeneficial
Large
Lactobacillus fermentum HA-179Reduced Postprandial Glucose LevelsBeneficial
Large
Lactobacillus fermentum Lf-33Enhanced Feruloyl Esterase ActivityBeneficial
Moderate
Lactobacillus fermentum Lf-33Improved Gut Microbiome CompositionBeneficial
Moderate
Lactobacillus fermentum Lf-33Improved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentum Lf-33Improved Insulin SensitivityBeneficial
Moderate
Lactobacillus fermentum Lf-33Improved Lipid ProfileBeneficial
Moderate
Lactobacillus fermentum Lf-33Improved Oxidative StatusBeneficial
Moderate
Lactobacillus fermentum Lf-33Reduced Adiposity IndexBeneficial
Large
Lactobacillus fermentum Lf-33Reduced Body WeightBeneficial
Moderate
Lactobacillus fermentum Lf-33Reduced Fasting Blood Sugar LevelsBeneficial
Large
Lactobacillus fermentum Lf-33Reduced Fatty Infiltration in HepatocytesBeneficial
Moderate
Lactobacillus fermentum Lf-33Reduced Plasma Leptin LevelsBeneficial
Large
Lactobacillus fermentum Lf-33Reduced Postprandial Glucose LevelsBeneficial
Large
Lactobacillus fermentum LF61Elevated 3-Hydroxyphenylpropionic Acid LevelsBeneficial
Moderate
Lactobacillus fermentum LF61Improved HOMA IndexBeneficial
Large
Lactobacillus fermentum LF61Improved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentum LF61Improved Oxidative StatusBeneficial
Moderate
Lactobacillus fermentum LF61Increased Bacteroidetes AbundanceBeneficial
Moderate
Lactobacillus fermentum LF61Increased Butyric Acid LevelsBeneficial
Moderate
Lactobacillus fermentum LF61Increased HDL Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum LF61Increased Intestinal Ferrochelatase ActivityBeneficial
Moderate
Lactobacillus fermentum LF61Reduced Fasting Blood Sugar LevelsBeneficial
Large
Lactobacillus fermentum LF61Reduced Fatty Infiltration in HepatocytesBeneficial
Moderate
Lactobacillus fermentum LF61Reduced Firmicutes AbundanceBeneficial
Moderate
Lactobacillus fermentum LF61Reduced Insulin LevelsBeneficial
Large
Lactobacillus fermentum LF61Reduced LDL CholesterolBeneficial
Large
Lactobacillus fermentum LF61Reduced Plasma Leptin LevelsBeneficial
Large
Lactobacillus fermentum LF61Reduced Postprandial Glucose LevelsBeneficial
Large
Lactobacillus fermentum LF61Reduced Risk Factors for Multiple SclerosisBeneficial
Large
Lactobacillus fermentum LF61Reduced Triglyceride LevelsBeneficial
Moderate
Lactobacillus fermentum LF61Reduced Weight GainBeneficial
Moderate
Lactobacillus fermentum MAK20L13FImproved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentum MAK20L13FImproved Insulin SensitivityBeneficial
Moderate
Lactobacillus fermentum MAK20L13FImproved Lipid ProfileBeneficial
Moderate
Lactobacillus fermentum MAK20L13FImproved Oxidative StatusBeneficial
Moderate
Lactobacillus fermentum MAK20L13FIncreased Bacteroidetes AbundanceBeneficial
Moderate
Lactobacillus fermentum MAK20L13FIncreased Butyric Acid LevelsBeneficial
Moderate
Lactobacillus fermentum MAK20L13FIncreased Feruloyl Esterase Activity in the IntestineBeneficial
Moderate
Lactobacillus fermentum MAK20L13FReduced Adiposity IndexBeneficial
Large
Lactobacillus fermentum MAK20L13FReduced Body WeightBeneficial
Moderate
Lactobacillus fermentum MAK20L13FReduced Fasting Blood Sugar LevelsBeneficial
Large
Lactobacillus fermentum MAK20L13FReduced Fatty Infiltration in HepatocytesBeneficial
Moderate
Lactobacillus fermentum MAK20L13FReduced Firmicutes AbundanceBeneficial
Moderate
Lactobacillus fermentum MAK20L13FReduced Insulin LevelsBeneficial
Large
Lactobacillus fermentum MAK20L13FReduced Plasma Leptin LevelsBeneficial
Large
Lactobacillus fermentum MAK20L13FReduced Postprandial Glucose LevelsBeneficial
Large
Lactobacillus fermentum ME-3Improved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentum ME-3Improved Insulin SensitivityBeneficial
Moderate
Lactobacillus fermentum ME-3Improved Lipid ProfileBeneficial
Moderate
Lactobacillus fermentum ME-3Improved Oxidative StatusBeneficial
Moderate
Lactobacillus fermentum ME-3Reduced Postprandial Glucose LevelsBeneficial
Large
Lactobacillus fermentum ME-3Reduced Weight GainBeneficial
Moderate
Lactobacillus fermentum UALf-32Improved Glucose ToleranceBeneficial
Moderate
Lactobacillus fermentum UALf-32Improved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentum UALf-32Improved Intestinal Microbiota CompositionBeneficial
Moderate
Lactobacillus fermentum UALf-32Improved Lipid ProfileBeneficial
Moderate
Lactobacillus fermentum UALf-32Reduced Plasma Leptin LevelsBeneficial
Large
Lactobacillus fermentum VPro 14Improved Inflammatory ProfileBeneficial
Moderate
Lactobacillus fermentum VPro 14Improved Lipid ProfileBeneficial
Moderate
Lactobacillus fermentum VPro 14Improved Oxidative StatusBeneficial
Moderate
Lactobacillus fermentum VPro 14Improved Postprandial Glucose LevelsBeneficial
Moderate
Lactobacillus fermentum VPro 14Increased Feruloyl Esterase Activity in the IntestineBeneficial
Moderate
Lactobacillus fermentum VPro 14Modulated Gut MicrobiotaBeneficial
Moderate
Lactobacillus fermentum VPro 14Reduced Fatty Infiltration in HepatocytesBeneficial
Moderate
Lactobacillus fermentum VPro 14Reduced Plasma Leptin LevelsBeneficial
Large
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