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Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.

  • 2004-12
  • Journal of the American Academy of Dermatology 51(6)
    • Maritza A Middelkamp-Hup
    • Madhu A Pathak
    • Concepcion Parrado
    • David Goukassian
    • Francisca Rius-Díaz
    • Martín C Mihm
    • Thomas B Fitzpatrick
    • Salvador González

Study Design

Type
Clinical Trial
Population
9 healthy participants of skin types II to III
Methods
Exposure to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg); paired biopsy specimens obtained from PL-treated and untreated skin

Background

UV radiation induces damage to human skin. Protection of skin by an oral photoprotective agent would have substantial benefits. Objective We investigated the photoprotective effect of oral administration of an extract of the natural antioxidant Polypodium leucotomos (PL).

Methods

A total of 9 healthy participants of skin types II to III were exposed to varying doses of artificial UV radiation without and after oral administration of PL (7.5 mg/kg). At 24 hours after exposure the erythema reaction was assessed and paired biopsy specimens were obtained from PL-treated and untreated skin.

Results

A significant decrease in erythema was found in PL-treated skin (P < .01). Histologically, PL-treated biopsy specimens showed less sunburn cells (P < .05), cyclobutane pyrimidine dimers (P < .001), proliferating epidermal cells (P < .001), and dermal mast cell infiltration (P < .05). A trend toward Langerhans cell preservation was seen.

Conclusion

Oral administration of PL is an effective systemic chemophotoprotective agent leading to significant protection of skin against UV radiation.

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