Persian Herbal Medicine in Functional Dyspepsia: A Systematic Review.

2021-02-19
Current drug discovery technologies 18(2)
- Maryam Azimi
- Mohammad Javad Zahedi

PubMed: 32525777
DOI: 10.2174/1570163817666200611132831

Study Design

Type: Systematic Review
Methods: Electronic databases were searched for clinical articles related to dyspepsia and herbal medicine by July 2019. Excluded all articles except Persian clinical trials.

Introduction

According to Rome IV, functional dyspepsia is diagnosed with the presence of dyspepsia in the absence of organic or metabolic causes. FD caused by several factors, such as impaired gastric accommodation and hypersensitivity to gastric distention. Several studies have reported the effectiveness of herbal medicine on FD. This article, thus, reviews Persian herbal medicine in FD.

Methods

Electronic databases, including Pubmed, Scopus, Cochrane, Embase, Web of science and Ovid, were searched so as to find clinical articles related to dyspepsia and herbal medicine by July 2019. Our search strategies were traditional medicine, complementary and alternative medicine, herb, plant, and dyspepsia. We excluded all articles except Persian clinical trials.

Results

We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like Asparagus racemosus, Brassica oleracea, Cynara scolymus, Ocimum basilicum, Mentha longifolia, Mentha pulegium, Mentha piperata, Pimpinella anisum, Nigella sativa, Mastic gum, Curcuma longa, Pistatio Atlantica, Glycyrrhiza glabra, Solanum tuberosum and Zingiber officinale and compound remedies of Rosa damascene & Crocus sativus, Trachyspermum copticom & Apium graveolence, Carum carvi & Mentha pipperata, Gingiber officinalis & Cynara scolymus are effective in functional dyspepsia.

Conclusion

Many people use herbal and traditional remedies for the treatment of disorders such as gastrointestinal disorders, especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD.

Research Insights

Anise→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Artichoke→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Basil→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Black Cumin→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Cabbage→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Caraway→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Ginger→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Licorice→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Mastic→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Mint→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Pennyroyal→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Potato→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Saffron→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Shatavari→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small
Turmeric→Improved Functional Dyspepsia Symptoms
We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like ... Gingiber officinalis & Cynara scolymus, ... are effective in functional dyspepsia.
Effect
Beneficial
Effect size
Small