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Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.

  • 2025-01-31
  • Pharmaceuticals (Basel, Switzerland) 18(2)
    • Quintero Vargas Jael Teresa de Jesús
    • Juan-Carlos Gálvez-Ruíz
    • Adriana Alejandra Márquez Ibarra
    • Mario-Alberto Leyva-Peralta

Study Design

Type
Review
Berberine is a promising agent for modulating the intestinal microbiota, playing a crucial role in human health homeostasis. This natural compound promotes the growth of beneficial bacteria such as Bacteroides, Bifidobacterium, and Lactobacillus while reducing harmful bacteria such as Escherichia coli. Clinical and preclinical studies demonstrate that Berberine helps regulate T2D and metabolic disorders, improves blood glucose levels during T2D, and reduces lipid profile and chronic inflammation, especially when combined with probiotics. Berberine represents a promising adjuvant therapy for inflammatory diseases, particularly intestinal disorders, due to its multifaceted actions of inhibiting proinflammatory cytokines and pathways during IBS, IBD, and UC and its modulation of gut microbiota and/or enhancement of the integrity of the intestinal epithelial barrier. This review establishes the basis for future treatment protocols with berberine and fully elucidates its mechanisms.

Research Insights

  • Bifidobacterium breve Bb-18→Improved Blood Glucose Control

    Clinical and preclinical studies demonstrate that Berberine helps regulate T2D and metabolic disorders, improves blood glucose levels during T2D...

    Effect
    Beneficial
    Effect size
    Moderate
  • Bifidobacterium breve Bb-18→Improved Gut Microbiota Composition

    Berberine is a promising agent for modulating the intestinal microbiota... This natural compound promotes the growth of beneficial bacteria such as Bacteroides, Bifidobacterium, and Lactobacillus while reducing harmful bacteria such as Escherichia coli.

    Effect
    Beneficial
    Effect size
    Moderate
  • Bifidobacterium breve Bb-18→Reduced Inflammation

    Berberine represents a promising adjuvant therapy for inflammatory diseases... due to its multifaceted actions of inhibiting proinflammatory cytokines and pathways during IBS, IBD, and UC.

    Effect
    Beneficial
    Effect size
    Moderate
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