Bifidobacterium breve Bb-18 and Reduced Inflammation

• Glucose Parameters, Inflammation Markers, and Gut Microbiota Changes of Gut Microbiome-Targeted Therapies in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  • 2025-06-09
  • Meta-Analysis · n = 3,390
  • The Journal of clinical endocrinology and metabolism 110(10)
  • • Xin Zhou
    • Wenbin Zheng
    • Wen Kong
    • Jiaoyue Zhang
    • Yunfei Liao
    • Jie Min
    • Tianshu Zeng

  • PubMed: 40489582
  • DOI: 10.1210/clinem/dgaf340

  5 Insights on

  • Reduced Inflammation

  • High evidence

  MTTs supplementation reduced high-sensitivity C-reactive protein, tumor necrosis factor alpha, and lipopolysaccharides. Meanwhile, the levels of interleukin-10 were increased.

  Effect

  Beneficial

  Effect size

  Small

• Elucidating the Probiotic Potential of Lactobacillus and Bifidobacterium Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A Scoping Review.

  • 2025-12-10
  • Systematic Review
  • Nutrition reviews 84(5)
  • • Sidra A Uzair
    • Angela Ajeesh
    • Salma H Ahmed
    • Shaikha Alabduljabbar
    • Fatima Ahmad
    • Arun P Lakshmanan
    • Annalisa Terranegra

  • PubMed: 41370015
  • DOI: 10.1093/nutrit/nuaf238

  3 Insights on

  • Reduced Inflammation

  • High evidence

  Probiotic interventions also favorably modulated inflammatory markers (high-sensitivity C-reactive protein, interleukin-6 [IL-6], and tumor necrosis factor-α).

  Effect

  Beneficial

  Effect size

  Moderate

• Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial.

  • 2025-08-23
  • RCT
  • Nutrients 17(17)
  • • Brooke A Napier
    • Jessica R Allegretti
    • Paul Feuerstadt
    • Colleen R Kelly
    • Nicholas W Van Hise
    • Ralf Jäger
    • Zain Kassam
    • Gregor Reid

  • PubMed: 40944126
  • DOI: 10.3390/nu17172734

  2 Insights on

  • Reduced Inflammation

  • High evidence
  • Rigorous Journal

  and was associated with reduced systemic inflammation.

  Effect

  Beneficial

  Effect size

  Small

• Perspectives on Berberine and the Regulation of Gut Microbiota: As an Anti-Inflammatory Agent.

  • 2025-01-31
  • Review
  • Pharmaceuticals (Basel, Switzerland) 18(2)
  • • Quintero Vargas Jael Teresa de Jesús
    • Juan-Carlos Gálvez-Ruíz
    • Adriana Alejandra Márquez Ibarra
    • Mario-Alberto Leyva-Peralta

  • PubMed: 40006007
  • DOI: 10.3390/ph18020193

  4 Insights on

  • Reduced Inflammation

  • Low evidence

  Berberine represents a promising adjuvant therapy for inflammatory diseases... due to its multifaceted actions of inhibiting proinflammatory cytokines and pathways during IBS, IBD, and UC.

  Effect

  Beneficial

  Effect size

  Moderate