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Phytoestrogens in osteoporosis.

  • 2025-01-01
  • Wiadomosci lekarskie (Warsaw, Poland : 1960) 78(3)
    • Mateusz Kaczmarski
    • Mateusz Trubalski
    • Paweł Kamiński
    • Marta Żerebiec
    • Aleksandra Bełżek
    • Natalia Saj
    • Zuzanna Rupeć
    • Joanna Niezbecka-Zając
    • Nataliia Fedorenko
    • Wojciech Kłapeć

Study Design

Type
Review
This article explores the role of phytoestrogens in the prevention and treatment of osteoporosis, focusing on soy isoflavones, red clover, and other plants such as Epimedium, hops, fennel, and prunes. It reviews clinical trials examining the effects of these phytoestrogens on bone mineral density (BMD), bone turnover markers, and osteoporotic fracture risk. Various studies demonstrate that phytoestrogens, particularly those derived from soy and red clover, may help improve bone health, alleviate menopausal symptoms, and reduce the risk of fractures. However, results regarding their impact on BMD are inconsistent, with some trials showing positive effects and others showing no significant difference compared to placebo. The article emphasizes the need for further, more comprehensive research to assess the long-term efficacy, safety, and mechanisms of action of phytoestrogens, considering individual patient characteristics such as genetics, metabolism, and lifestyle factors. While phytoestrogens hold promise as a potential complement or alternative to conventional osteoporosis therapies, personalized approaches to supplementation, as well as more rigorous studies, are necessary to establish their clinical benefits and minimize risks.

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