Across 3 studies, 2 reported beneficial effects of soy isoflavones on menopausal symptoms, with effect sizes ranging from small to moderate. The median study duration was 365 days, indicating effects observed over prolonged use. The most-studied dose was 60 mg/day in a clinical population of postmenopausal women.
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Two of the three studies showed statistically significant beneficial effects, but one neutral review did not reach significance. The median study duration is based on only one study, limiting generalizability.
mammographic density, endometrial thickness and hepatic function did not show significant differences between groups
from: Endometrial, breast and liver safety of soy isoflavones plus Lactobacillus sporogenes in psoy isoflavones were effective for treating menopausal symptoms (seven studies, 533 participants, Hedges' g = -0.25, 95% CI [-0.42 to -0.08], p = 0.00)
menopausal symptoms were progressively and significantly reduced in severity and frequency during treatment with soy isoflavones plus Lactobacillus sporogenes versus calcium plus vitamin D₃
alleviate menopausal symptoms