Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Pomegranate juice consumption and lipid profile: An updated systematic review and meta-analysis.

  • 2026-05-01
  • Avicenna journal of phytomedicine 16(3)
    • Fatemeh Ghaemi
    • Maryam Emadzadeh
    • Wael Almahmeed
    • Tannaz Jamialahmadi
    • Sercan Karav
    • Amirhossein Sahebkar

Study Design

Type
Review
Sample size
n = 663
Population
663 participants
Methods
Systematic review and meta-analysis of RCTs; comprehensive literature search across multiple databases

Objective

Pomegranate juice (PJ) is rich in polyphenols with potential lipid-lowering effects. This study aimed to evaluate the impact of PJ consumption on blood lipid parameters through a systematic review and meta-analysis of randomized controlled trials (RCTs).

Materials and methods

A comprehensive literature search was conducted across multiple databases to identify RCTs assessing the effects of PJ on lipid profiles in adults. A total of 17 RCTs involving 663 participants were included. Outcomes analyzed were changes in total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Subgroup and meta-regression analyses were performed based on dose, duration, and participant health status.

Results

PJ consumption was associated with significant reductions in TG (MD: -8.2 mg/dL) and LDL-C (MD: -4.8 mg/dL), and a significant increase in HDL-C (MD: +2.8 mg/dL). No overall effect was observed for TC. High heterogeneity was detected, partially explained by differences in PJ dose and population characteristics.

Conclusion

PJ may improve lipid profiles, particularly by reducing TG and LDL-C and increasing HDL-C levels. These effects appear more pronounced in populations with metabolic disorders. Future trials with standardized PJ formulations and longer durations are warranted.

Research Insights

Back to top