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Post-Exercise Hypotension after Exercising in Hypoxia with and Without Tart Cherry Supplementation.

  • 2025-03-01
  • High altitude medicine & biology 26(1)
    • Masahiro Horiuchi
    • Samuel J Oliver

Study Design

Type
Randomized Controlled Trial (RCT)
Population
12 healthy young adults (9 men and 3 women)
Methods
randomized order, cycle exercise to exhaustion in normoxia without any supplementation, in hypoxia with placebo, and in hypoxia with tart cherry supplementation
Duration
5 days pre-trial
Horiuchi, Masahiro, and Samuel J. Oliver. Post-exercise hypotension after exercising in hypoxia with and without tart cherry supplementation. High Alt Med Biol. 26:63-69, 2025. Background: This study investigated the effects of hypoxic exercise with and without tart cherry (TC) supplementation on post-exercise hypotension (PEH). Method: In a randomized order, 12 healthy young adults (9 men and 3 women) completed cycle exercise to exhaustion (1) in normoxia without any supplementation (Norm), (2) in hypoxia (13% O2) with placebo (Hypo), and (3) in hypoxia with TC supplementation (Hypo + TC). Supplements were supplied for 5 days pre-trial (TC was 200 mg anthocyanin per day for 4 days and 100 mg on day 5). Results: Cycle exercise total energy expenditure was greater in Norm than Hypo and Hypo + TC (p < 0.001) with no difference between Hypo and Hypo + TC (p = 0.41). Mean arterial pressure (MAP) decreased during recovery in all trials (main effect of time, p < 0.001), with no difference in PEH between the trials (p > 0.05, change [Δ] in MAP from pre-exercise at 60 minutes recovery, mean difference, Norm Δ-4.4 mmHg, Hypo Δ-6.1 mmHg, and Hypo + TC Δ-5.2 mmHg). Cardiac baroreflex sensitivity decreased during recovery in all trials (p < 0.001) and was lower in Hypo than Norm and Hypo + TC (main effect of trial, p = 0.02). Conclusion: PEH was not increased after exercise in hypoxia, with or without TC supplementation, compared with exercise in normoxia.

Research Insights

  • tart cherry→Improved Cardiac Baroreflex Sensitivity

    Cardiac baroreflex sensitivity decreased during recovery in all trials (p < 0.001) and was lower in Hypo than Norm and Hypo + TC (main effect of trial, p = 0.02).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    200 mg anthocyanin per day for 4 days and 100 mg on day 5
  • tart cherry→Reduced Mean Arterial Pressure

    Mean arterial pressure (MAP) decreased during recovery in all trials (main effect of time, p < 0.001), with no difference in PEH between the trials (p > 0.05, change [Δ] in MAP from pre-exercise at 60 minutes recovery, mean difference, Norm Δ-4.4 mmHg, Hypo Δ-6.1 mmHg, and Hypo + TC Δ-5.2 mmHg).

    Effect
    Neutral
    Effect size
    Small
    Dose
    200 mg anthocyanin per day for 4 days and 100 mg on day 5
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