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Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

  • 2020-03-26
  • Frontiers in Microbiology 11
    • Huizhen Li
    • Fei Liu
    • Jingjing Lu
    • Jialu Shi
    • Jiaqi Guan
    • Fenfen Yan
    • Bailiang Li
    • G. Huo

Abstract

The global prevalence of obesity is rising year by year, which has become a public health problem worldwide. In recent years, animal studies and clinical studies have shown that some lactic acid bacteria possess an anti-obesity effect. In our previous study, mixed lactobacilli (Lactobacillus plantarum KLDS1.0344 and Lactobacillus plantarum KLDS1.0386) exhibited anti-obesity effects in vivo by significantly reducing body weight gain, Lee's index and body fat rate; however, its underlying mechanisms of action remain unclear. Therefore, the present study aims to explore the possible mechanisms for the inhibitory effect of mixed lactobacilli on obesity. C57BL/6J mice were randomly divided into three groups including control group (Control), high fat diet group (HFD) and mixed lactobacilli group (MX), and fed daily for eight consecutive weeks. The results showed that mixed lactobacilli supplementation significantly improved blood lipid levels and liver function, and alleviated liver oxidative stress. Moreover, the mixed lactobacilli supplementation significantly inhibited lipid accumulation in the liver and regulated lipid metabolism in epididymal fat pads. Notably, the mixed lactobacilli treatment modulated the gut microbiota, resulting in a significant increase in acetic acid and butyric acid. Additionally, Spearman's correlation analysis found that several specific genera were significantly correlated with obesity-related indicators. These results indicated that the mixed lactobacilli supplementation could manipulate the gut microbiota and its metabolites (acetic acid and butyric acid), resulting in reduced liver lipid accumulation and improved lipid metabolism of adipose tissue, which inhibited obesity.

Keywords: Lactobacillus plantarum; gut microbiota; lipid accumulation; lipid metabolisim; obesity; short chain fatty acids.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus Bulgaricus & Lactobacillus PlantarumAltered Gut MicrobiotaBeneficial
Large
Lactobacillus Bulgaricus & Lactobacillus PlantarumImproved Lipid MetabolismBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumIncreased Short-Chain Fatty Acid LevelsBeneficial
Large
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced Hepatic Lipid AccumulationBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced ObesityBeneficial
Large
Lactobacillus plantarumAltered Gut MicrobiotaBeneficial
Large
Lactobacillus plantarumImproved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarumImproved Liver FunctionBeneficial
Moderate
Lactobacillus plantarumReduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarumReduced Liver Lipid AccumulationBeneficial
Moderate
Lactobacillus plantarum 14DImproved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum 14DReduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarum 14DReduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum 14DReduced Liver Lipid AccumulationBeneficial
Moderate
Lactobacillus plantarum DR7Improved Gut Microbiota StructureBeneficial
Moderate
Lactobacillus plantarum DR7Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum DR7Reduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarum DR7Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum DR7Reduced Liver Lipid AccumulationBeneficial
Moderate
Lactobacillus plantarum HEAL9Enhanced Lipid Metabolism in Adipose TissueBeneficial
Moderate
Lactobacillus plantarum HEAL9Reduced Body WeightBeneficial
Large
Lactobacillus plantarum KABP™-061Altered Gut MicrobiotaBeneficial
Large
Lactobacillus plantarum KABP™-061Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Body WeightBeneficial
Large
Lactobacillus plantarum KABP™-061Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Liver Lipid AccumulationBeneficial
Moderate
Lactobacillus plantarum N13Reduced ObesityBeneficial
Large
Lactobacillus plantarum R1012Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum R1012Improved Liver FunctionBeneficial
Moderate
Lactobacillus plantarum R1012Reduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarum R1012Reduced Body WeightBeneficial
Large
Lactobacillus plantarum R1012Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum R1012Reduced Liver Lipid AccumulationBeneficial
Moderate
Lactobacillus plantarum R1012Regulated Lipid Metabolism in Epididymal Fat PadsBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Blood Lipid MetabolismBeneficial
Large
Lactobacillus plantarum Rosell-AImproved Liver FunctionBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Hepatic Lipid AccumulationBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Obesity IndicatorsBeneficial
Large
Lactobacillus plantarum SD5209Altered Gut MicrobiotaBeneficial
Large
Lactobacillus plantarum SD5209Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum SD5209Improved Liver FunctionBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Liver Lipid AccumulationBeneficial
Moderate
Lactobacillus plantarum WCFS1Altered Gut MicrobiotaBeneficial
Large
Lactobacillus plantarum WCFS1Improved Lipid MetabolismBeneficial
Moderate
Lactobacillus plantarum WCFS1Improved Liver FunctionBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced Blood Lipid LevelsBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced Body WeightBeneficial
Large
Lactobacillus plantarum WCFS1Reduced Hepatic Oxidative StressBeneficial
Moderate
Lactobacillus plantarum WCFS1Reduced Liver Lipid AccumulationBeneficial
Moderate
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