Probiotics and prebiotics: new treatment strategies for oral potentially malignant disorders and gastrointestinal precancerous lesions.

2025-04-08
NPJ biofilms and microbiomes 11(1)

PubMed: 40199865
DOI: 10.1038/s41522-025-00688-9

Study Design

Type: Review
Methods: This review aims to comprehensively review the application status of probiotics, prebiotics and engineered probiotics in OPMDs and GPLs, explore their potential mechanisms of action, and anticipate their future clinical use.

Oral potentially malignant disorders (OPMDs) and gastrointestinal precancerous lesions (GPLs) are major public health concerns because of their potential to progress to cancer. Probiotics, prebiotics, and engineered probiotics can positively influence the prevention and management of OPMDs and GPLs. This review aims to comprehensively review the application status of probiotics, prebiotics and engineered probiotics in OPMDs and GPLs, explore their potential mechanisms of action, and anticipate their future clinical use.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Lactobacillus reuteri ATCC PTA 5289	—	Reduced Oral Pathogen Growth	Beneficial	Small	View source Lactobacillus reuteri ATCC PTA 5289 has been associated with reduced levels of oral pathogens in studies of oral health interventions.