Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review.
- 2021-03-25
- Foods (Basel, Switzerland) 10(4)
- Aroa Lopez-Santamarina
- Esther Gonzalez Gonzalez
- Alexandre Lamas
- Alicia Del Carmen Mondragon
- Patricia Regal
- Jose Manuel Miranda
- PubMed: 33806092
- DOI: 10.3390/foods10040701
Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and for this reason, alternatives for the treatment of allergic diseases or reduction in their symptoms are being sought. The main objective of this study was to compile the studies carried out on probiotics as a possible therapy for allergies. The most studied allergies on which probiotics have been shown to have a beneficial effect are rhinitis, asthma, and atopic dermatitis. Most studies have studied the administration of Lactobacillus and Bifidobacterium spp. in children and have shown beneficial effects, such as a reduction in hyperreactivity and inflammation caused by allergens and a decrease in cytokine release, among other beneficial effects. In the case of children, no clear beneficial effects were found in several studies, and the potential risk from the use of some opportunistic bacteria, such as probiotics, seems controversial. In the studies that reported beneficial results, these effects were found to make allergy symptoms less aggressive, thus reducing morbidity in allergy sufferers. The different effects of the same probiotic bacteria on different patients seem to reinforce the idea that the efficacy of probiotics is dependent on the microbial species or strain, its derived metabolites and byproducts, and the gut microbiota eubiosis of the patient. This study is relevant in the context of allergic diseases, as it provides a broader understanding of new alternatives for the treatment of allergies, both in children, who are the main sufferers, and adults, showing that probiotics, in some cases, reduce the symptoms and severity of such diseases.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus rhamnosus lysate powder | No Improvement in Allergy Symptoms | Beneficial | Small |
| Lactobacillus rhamnosus lysate powder | Reduced Allergen Hyperreactivity | Beneficial | Moderate |
| Lactobacillus rhamnosus lysate powder | Reduced Allergy Symptoms | Beneficial | Moderate |
| Lactobacillus rhamnosus lysate powder | Reduced Inflammation | Beneficial | Moderate |