Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: a randomized controlled trial.
- 2014-09
- Nutrition (Burbank, Los Angeles County, Calif.) 30(9)
- Eun-Soo Jung
- Soo-Hyun Park
- Eun-Kyung Choi
- Beun-Ho Ryu
- Byung-Hyun Park
- Dal-Sik Kim
- Young-Gon Kim
- Soo-Wan Chae
- PubMed: 24976429
- DOI: 10.1016/j.nut.2014.02.014
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 28
- Population
- 28 participants in the ABG group and 27 in the placebo group, all with mild hypercholesterolemia
- Methods
- double-blind, randomized placebo-controlled trial; 6 g/d aged black garlic (ABG) or placebo twice daily before meals for 12 wk
- Blinding
- Double-blind
- Duration
- 12 wk
- Funding
- Unclear
Objective
The cholesterol-lowering effects of garlic as part of a healthy diet remain controversial. The aim of this study was to investigate whether supplementation with aged black garlic (ABG) could improve blood lipid profiles in patients with mild hypercholesterolemia.Methods
We conducted a double-blind, randomized placebo-controlled trial. Sixty participants were randomly assigned to receive either ABG or placebo twice daily (total 6 g/d) before consumption of a meal every morning and evening for 12 wk. During the study, two participants dropped out of the ABG group, and three participants dropped out of the placebo group. Thus, the effects of AGB on fasting blood levels of lipids were evaluated in 28 participants and compared with the placebo group (n = 27).Results
Among lipid components, no significant differences in triglycerides, low-density lipoprotein cholesterol, total cholesterol, or free fatty acid levels were observed between the two groups. However, ABG increased high-density lipoprotein cholesterol levels compared with the placebo group at the end of the study. Moreover, a significant decrease in the levels of alipoprotein B and a significant increase in the ratio of low-density lipoprotein cholesterol/alipoprotein B were observed in the ABG group. No adverse effects were reported in any of the patients.Conclusion
ABG supplementation reduced atherogenic markers and thus may have a cardioprotective effect beyond the gold standard medication in patients with mild hypercholesterolemia.Research Insights
However, ABG increased high-density lipoprotein cholesterol levels compared with the placebo group at the end of the study.
- Effect
- Beneficial
- Effect size
- Small
- Dose
- 6 g/day
Moreover, a significant decrease in the levels of alipoprotein B and a significant increase in the ratio of low-density lipoprotein cholesterol/alipoprotein B were observed in the ABG group.
- Effect
- Beneficial
- Effect size
- Small
- Dose
- 6 g/day
Among lipid components, no significant differences in triglycerides, low-density lipoprotein cholesterol, total cholesterol, or free fatty acid levels were observed between the two groups.
- Effect
- Neutral
- Effect size
- Small
- Dose
- 6 g/day
Moreover, a significant decrease in the levels of alipoprotein B and a significant increase in the ratio of low-density lipoprotein cholesterol/alipoprotein B were observed in the ABG group.
- Effect
- Beneficial
- Effect size
- Small
- Dose
- 6 g/day
Among lipid components, no significant differences in triglycerides, low-density lipoprotein cholesterol, total cholesterol, or free fatty acid levels were observed between the two groups.
- Effect
- Neutral
- Effect size
- Small
- Dose
- 6 g/day
Among lipid components, no significant differences in triglycerides, low-density lipoprotein cholesterol, total cholesterol, or free fatty acid levels were observed between the two groups.
- Effect
- Neutral
- Effect size
- Small
- Dose
- 6 g/day
Adverse Events Reported
No adverse effects were reported in any of the patients.
- Finding
- Reported