Saccharomyces boulardii Stimulates Intestinal Immunoglobulin A Immune Response to Clostridium difficileToxin A in Mice
- 2001-04
- Infection and Immunity 69(4)
- A. Qamar
- Samer Aboudola
- M. Warny
- P. Michetti
- C. Pothoulakis
- J. Lamont
- C. Kelly
- PubMed: 11254650
- DOI: 10.1128/IAI.69.4.2762-2765.2001
Study Design
- Type
- Clinical Trial
- Population
- BALB/c mice
- Methods
- In vivo experiment with mice.
- Highly Cited
- Animal Study
Abstract
Saccharomyces boulardii is a nonpathogenic yeast that protects against antibiotic-associated diarrhea and recurrent Clostridium difficile colitis. The administration of C. difficile toxoid A by gavage to S. boulardii-fed BALB/c mice caused a 1.8-fold increase in total small intestinal immunoglobulin A levels (P = 0.003) and a 4.4-fold increase in specific intestinal anti-toxin A levels (P < 0.001). Enhancing host intestinal immune responses may be an important mechanism for S. boulardii-mediated protection against diarrheal illnesses.