Secondary Metabolites from <i>Bacillus</i> spp. probiotics as potential treatments for multidrug-resistant pathogens: A comprehensive review.
- 2025
- Current research in microbial sciences 8
- George Michael Nicolas
- PubMed: 40337641
- DOI: 10.1016/j.crmicr.2025.100392
The discovery of antibiotics is a significant medical breakthrough, saving millions of lives. However, the widespread misuse and overuse of antibiotics led to the development of antimicrobial resistance. Spore-forming probiotics from Bacillus spp. show great interest as antimicrobial agents through the production of strain-specific bioactive secondary metabolites. This review summarizes the broad-spectrum antimicrobial activities of Bacillus spp. secondary metabolite groups and their reported mechanisms of action, underscoring the urgency in developing novel antimicrobial drugs.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bacillus coagulans ProDura | Reduced Pathogen Growth | Beneficial | Moderate |