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Secondary Metabolites from Bacillus spp. probiotics as potential treatments for multidrug-resistant pathogens: A comprehensive review.

  • 2025-05-09
  • Current research in microbial sciences 8
    • George Michael Nicolas

Study Design

Type
Review
Methods
This review summarizes the broad-spectrum antimicrobial activities of Bacillus spp. secondary metabolite groups and their reported mechanisms of action.
The discovery of antibiotics is a significant medical breakthrough, saving millions of lives. However, the widespread misuse and overuse of antibiotics led to the development of antimicrobial resistance. Spore-forming probiotics from Bacillus spp. show great interest as antimicrobial agents through the production of strain-specific bioactive secondary metabolites. This review summarizes the broad-spectrum antimicrobial activities of Bacillus spp. secondary metabolite groups and their reported mechanisms of action, underscoring the urgency in developing novel antimicrobial drugs.

Research Insights

  • Bacillus clausii MTCC 5980→Reduced Pathogen Growth

    Spore-forming probiotics from Bacillus spp. show great interest as antimicrobial agents through the production of strain-specific bioactive secondary metabolites. This review summarizes the broad-spectrum antimicrobial activities of Bacillus spp. secondary metabolite groups and their reported mechanisms of action, underscoring the urgency in developing novel antimicrobial drugs.

    Effect
    Beneficial
    Effect size
    Moderate
  • Bacillus coagulans ProDura→Reduced Pathogen Growth

    Spore-forming probiotics from Bacillus spp. show great interest as antimicrobial agents through the production of strain-specific bioactive secondary metabolites. This review summarizes the broad-spectrum antimicrobial activities of Bacillus spp. secondary metabolite groups and their reported mechanisms of action, underscoring the urgency in developing novel antimicrobial drugs.

    Effect
    Beneficial
    Effect size
    Moderate
  • Bacillus subtilis SNZ-1972→Reduced Pathogen Activity

    This review summarizes the broad-spectrum antimicrobial activities of Bacillus spp. secondary metabolite groups and their reported mechanisms of action, underscoring the urgency in developing novel antimicrobial drugs.

    Effect
    Beneficial
    Effect size
    Moderate
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