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Short-term intestinal effects of water intake in fibre supplementation in healthy, low-habitual fibre consumers: a phase 2 clinical trial.

  • 2022-05-23
  • International journal of food sciences and nutrition 73(6)
    • Gissele V R Gonçalves
    • Raíssa Canova
    • Sidia M Callegari-Jacques
    • Rafael Frandoloso
    • Luiz C Kreutz
    • Fernando Fornari

Study Design

Type
Randomized Controlled Trial (RCT)
Population
20 healthy, low-habitual fibre consumers
Methods
Randomised clinical trial, 14 days of fibre supplementation with wheat bran, pectin, and green banana flour, with or without additional water intake (2 L/day)
Blinding
Open-label
Duration
14-days
A randomised clinical trial was conducted on 20 healthy, low-habitual fibre consumers to assess the short-term effects of water intake (2 l/day) on fibre supplementation with wheat bran, pectin, and green banana flour. During the 14-days trial, fibre intake doubled in both fibre (n = 10) and fibre/water (n = 10) interventions (p < 0.001), whereas daily water intake increased from 538 to 1990 ml in the fibre/water group (p < 0.001). Weekly bowel movements increased similarly in both interventions (fibre: 6.8-8.8; fibre/water: 8.6-10; p < 0.01), while faecal weight (71-126 g; p = 0.009) increased in the fibre/water group. This group showed higher counts of faecal Bacteroides and Prevotella, Faecalibacterium prausnitzii, and Bifidobacterium, whereas both interventions decreased the count of Desulfovibrio. Transient abdominal symptoms occurred less frequently in the fibre/water than in the fibre group (3 vs. 9 participants; p = 0.020). In healthy, low-habitual fibre consumers, short-term water intake helps the intestinal adaptation to fibre supplementation.CLINICAL TRIAL REGISTRATION NUMBER: NCT02838849.

Research Insights

  • Wheat→Increased Bacteroides Count

    This group showed higher counts of faecal Bacteroides and Prevotella, Faecalibacterium prausnitzii, and Bifidobacterium

    Effect
    Beneficial
    Effect size
    Small
    Dose
    Not specified (diet doubled fibre intake)
  • Wheat→Increased Bifidobacteria Count

    This group showed higher counts of faecal Bacteroides and Prevotella, Faecalibacterium prausnitzii, and Bifidobacterium

    Effect
    Beneficial
    Effect size
    Small
    Dose
    Not specified (diet doubled fibre intake)
  • Wheat→Increased Bowel Movements

    Weekly bowel movements increased similarly in both interventions (fibre: 6.8-8.8; fibre/water: 8.6-10; p<0.01)

    Effect
    Beneficial
    Effect size
    Small
    Dose
    Not specified (diet doubled fibre intake)
  • Wheat→Increased Faecalibacterium prausnitzii Levels

    This group showed higher counts of faecal Bacteroides and Prevotella, Faecalibacterium prausnitzii, and Bifidobacterium

    Effect
    Beneficial
    Effect size
    Small
    Dose
    Not specified (diet doubled fibre intake)
  • Wheat→Increased Fecal Weight

    faecal weight (71-126 g; p=0.009) increased in the fibre/water group

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    Not specified (diet doubled fibre intake)
  • Wheat→Increased Prevotella Count

    This group showed higher counts of faecal Bacteroides and Prevotella, Faecalibacterium prausnitzii, and Bifidobacterium

    Effect
    Beneficial
    Effect size
    Small
    Dose
    Not specified (diet doubled fibre intake)
  • Wheat→Reduced Desulfovibrio Count

    both interventions decreased the count of Desulfovibrio

    Effect
    Beneficial
    Effect size
    Small
    Dose
    Not specified (diet doubled fibre intake)
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