The Effect of Bifidobacterium animalis ssp. lactis HN019 on Cellular Immune Function in Healthy Elderly Subjects: Systematic Review and Meta-Analysis
- 2017-02-24
- Nutrients 9(3)
- L. Miller
- L. Lehtoranta
- M. Lehtinen
- PubMed: 28245559
- DOI: 10.3390/nu9030191
Abstract
Elderly people have increased susceptibility to infections and cancer that are associated with decline in cellular immune function. The objective of this work was to determine the efficacy of Bifidobacterium (B.) animalis ssp. lactis HN019 (HN019) supplementation on cellular immune activity in healthy elderly subjects. We conducted a systematic review of Medline and Embase for controlled trials that reported polymorphonuclear (PMN) cell phagocytic capacity or natural killer (NK) cell tumoricidal activity following B. lactis HN019 consumption in the elderly. A random effects meta-analysis was performed with standardized mean difference (SMD) and 95% confidence interval between probiotic and control groups for each outcome. A total of four clinical trials were included in this analysis. B. lactis HN019 supplementation was highly efficacious in increasing PMN phagocytic capacity with an SMD of 0.74 (95% confidence interval: 0.38 to 1.11, p < 0.001) and moderately efficacious in increasing NK cell tumoricidal activity with an SMD of 0.43 (95% confidence interval: 0.08 to 0.78, p = 0.02). The main limitations of this research were the small number of included studies, short-term follow-up, and assessment of a single probiotic strain. In conclusion, daily consumption of B. lactis HN019 enhances NK cell and PMN function in healthy elderly adults.
Keywords: Bifidobacterium; aging; elderly; immunity; probiotic.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium animalis | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium animalis | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis B420 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis B420 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis BLC1 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BLC1 | Improved Phagocytic Capacity of Polymorphonuclear Cells | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis BS-01 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis BS-01 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis CECT 8145 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis HN019 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis HN019 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium animalis subsp. lactis VK2 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium animalis subsp. lactis VK2 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium bifidum/lactis Bb-02 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium bifidum/lactis Bb-02 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis B420 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis B420 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis BI-04 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis BI-04 | Improved Polymorphonuclear Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis Bi-07 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis Bi-07 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis BL818 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis BL818 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis BLA80 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis BLA80 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis BLC-1 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis BLC-1 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis BS01 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis BS01 | Improved Polymorphonuclear Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis HA-194 | Enhanced Natural Killer Cell Tumor Killing Activity | Beneficial | Moderate |
| Bifidobacterium lactis HA-194 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis HN019 | Enhanced Natural Killer Cell Tumor Killing Activity | Beneficial | Moderate |
| Bifidobacterium lactis HN019 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis ISS Bif | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis ISS Bif | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis MAK16B42L | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis MAK16B42L | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis R101-8 | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis R101-8 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis SD-5219 | Enhanced Natural Killer Cell Tumor Killing Activity | Beneficial | Moderate |
| Bifidobacterium lactis SD-5219 | Improved Phagocytic Capacity of Polymorphonuclear Cells | Beneficial | Large |
| Bifidobacterium lactis UABla-12 | Improved Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis UABla-12 | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |
| Bifidobacterium lactis/longum | Enhanced Natural Killer Cell Tumoricidal Activity | Beneficial | Moderate |
| Bifidobacterium lactis/longum | Increased PMN Cell Phagocytic Capacity | Beneficial | Large |