The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial.
- 2019-09-04
- Complementary medicine research 27(1)
- Hamidreza Ardalani
- Parisa Jandaghi
- Aramsadat Meraji
- Maryam Hassanpour Moghadam
- PubMed: 31484191
- DOI: 10.1159/000502280
Study Design
- Type
- Randomized Controlled Trial (RCT)
- Sample size
- n = 40
- Population
- 40 hypertensive patients
- Methods
- Clinical trial, 8 weeks of C. scolymus 500 mg twice daily vs placebo
- Duration
- 8 weeks
Background
Recent studies have suggested that artichoke (Cynara scolymus L.) may reduce certain biochemical blood factors but the efficacy of this plant on blood pressure (BP) has not yet been investigated. In this study, we determined the clinical efficacy of C. scolymuson BP and body mass index (BMI) in hypertensive patients as an adjunctive to captopril for the first time.Methods
The total phenolic content and gas chromatography-mass spectrometry metabolite profiling in leaves of C. scolymus have been evaluated. A clinical trial was subsequently carried out on 40 patients to determine the effect of C. scolymus on BP and BMI in hypertensive patients. The treatment group received capsules containing C. scolymus(500 mg twice daily) and the placebo group received starch powder for 8 weeks. Systolic blood pressure (SBP), diastolic blood pressure, and BMI were determined before and after the study.Results
A significant improvement of the BMI was seen in the C. scolymus group compared with the placebo group (p = 0.04).Conclusions
Our findings demonstrated that the consumption of C. scolymus powder as a rich source of phenolic and antioxidant compounds could potentially improve BMI and SBP in hypertensive patients. Therefore, more trials are needed to confirm or reject the antihypertensive impact of artichoke.Research Insights
A significant improvement of the BMI was seen in the C. scolymus group compared with the placebo group (p = 0.04).
- Effect
- Beneficial
- Effect size
- Small
- Dose
- 500 mg twice daily
Systolic blood pressure (SBP), diastolic blood pressure, and BMI were determined before and after the study.
- Effect
- Neutral
- Effect size
- Small
- Dose
- 500 mg twice daily
Our findings demonstrated that the consumption of C. scolymus powder as a rich source of phenolic and antioxidant compounds could potentially improve BMI and SBP in hypertensive patients.
- Effect
- Neutral
- Effect size
- Small
- Dose
- 500 mg twice daily