Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials.

  • 2022-07-20
  • Phytotherapy research : PTR 36(10)
    • Trias Mahmudiono
    • Saade Abdalkareem Jasim
    • Yasir Salam Karim
    • Dmitry Olegovich Bokov
    • Walid Kamal Abdelbasset
    • Kholmurod S Akhmedov
    • Ghulam Yasin
    • Lakshmi Thangavelu
    • Yasser Fakri Mustafa
    • Shehla Shoukat
    • Mazin A A Najm
    • Mohammad Amraei

Study Design

Type
Meta-Analysis
Population
patients with metabolic syndrome and related disorders
Methods
systematic review and meta-analysis of RCTs; databases searched until March 31, 2020; random-effects model
We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model. Standard methods were used for the assessment of heterogeneity, sensitivity analysis, and publication bias. Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: -3.86 mmHg, 95% CI: -7.59 to -0.13, p = .04) BP (SBP) after flaxseed oil consumption. However, the overall effect illustrated no significant change in diastolic (WMD: -1.71 mmHg, 95% CI: -3.67 to 0.26, p = .09) BP (DBP) in the intervention group compared with the control group. Our findings revealed that flaxseed oil consumption has favorable effects on SBP in patients with metabolic syndrome and related disorders. However, further investigations are needed to provide more reliable evidence.

Research Insights

  • Flax→Reduced Diastolic Blood Pressure

    the overall effect illustrated no significant change in diastolic (WMD: -1.71 mmHg, 95% CI: -3.67 to 0.26, p = .09) BP (DBP) in the intervention group compared with the control group.

    Effect
    Neutral
    Effect size
    Small
  • Flax→Reduced Systolic Blood Pressure

    Meta-analysis of five trials (6 arms) showed significant reductions in systolic (WMD: -3.86 mmHg, 95% CI: -7.59 to -0.13, p = .04) BP (SBP) after flaxseed oil consumption.

    Effect
    Beneficial
    Effect size
    Small
Back to top