The effect of probiotics on gestational diabetes and its complications in pregnant mother and newborn: A systematic review and meta-analysis during 2010-2020.
- 2022-03-03
- Journal of clinical laboratory analysis 36(4)
- Marzie Mahdizade Ari
- Samane Teymouri
- Tayebeh Fazlalian
- Parisa Asadollahi
- Roghayeh Afifirad
- Mohammad Sabaghan
- Fateme Valizadeh
- Roya Ghanavati
- Atieh Darbandi
- PubMed: 35243684
- DOI: 10.1002/jcla.24326
This study was aimed to evaluate the effect of probiotics consumption on gestational diabetes (GD) and its complications in pregnant mother and newborn. The study was registered on PROSPERO (CRD42021243409) and all the enrolled articles were collected from four databases (Medline, Scopus, Embase, and Google Scholar) as randomized controlled trials (RCTs) from 2010 to 2020. A total of 4865 study participants from 28 selected studies were included in this review. The present meta-analysis showed that the consumption of probiotics supplementation has the potential to decrease GD-predisposing metabolic parameters such as blood glucose level, lipid profile, inflammation, and oxidative markers which may reduce GD occurrence among pregnant women.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus salivarius UCC118 | Reduced Prevalence of Gestational Diabetes Mellitus | Beneficial | Moderate |