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Lactobacillus salivarius UCC118 and Reduced Prevalence of Gestational Diabetes Mellitus

Research synthesisModerate evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing the prevalence of gestational diabetes mellitus, with effect sizes ranging from small to moderate. Two of four studies found statistically significant risk reductions, with one meta-analysis reporting a 48% lower risk (RR 0.52, p=0.003) and another reporting a 29% lower risk (RR 0.71, p=0.03). Evidence predominantly comes from meta-analyses of probiotic interventions in pregnant women, though the specific dose and duration are not consistently reported.

  • Studied populations: pregnant women

Caveats: Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). The studies do not consistently isolate Lactobacillus salivarius UCC118 as the sole intervention, making it difficult to attribute effects specifically to this strain versus mixed probiotics.

Generated Jun 11, 2026
4 of 4 papers
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