Best Supplements for Reduced Prevalence of Gestational Diabetes Mellitus
Ranked by research evidence. Compare 4 supplements across 11 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 (as part of probiotic supplementation) on reducing gestational diabetes mellitus prevalence, with moderate effect sizes in three studies and a small effect in one. Two of the four studies reported statistically significant findings. The evidence comes primarily from meta-analyses and a narrative review, though no study isolated this specific strain or specified a dose.
- Low evidence4 studies
Across 4 studies, 3 reported beneficial effects (1 moderate-sized, statistically significant effect from a meta-analysis) and 1 reported no effect from an RCT. The predominant effect size is mixed: the highest-quality study (an RCT) found a null/neutral effect, while a meta-analysis of 14 trials showed a moderate beneficial reduction in GDM incidence (RR 0.71, 95% CI 0.52–0.96). No consistent dose was reported, and the evidence primarily pertains to pregnant women, including those at high risk or overweight/obese.
- ModerateLactobacillus salivarius UCC118Across 4 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 (as part of probiotic supplementation) on reducing gestational diabetes mellitus prevalence, with moderate effect sizes in three studies and a small effect in one. Two of the four studies reported statistically significant findings. The evidence comes primarily from meta-analyses and a narrative review, though no study isolated this specific strain or specified a dose.4 beneficial4 studies
- LowBifidobacterium longum SP54Across 4 studies, 3 reported beneficial effects (1 moderate-sized, statistically significant effect from a meta-analysis) and 1 reported no effect from an RCT. The predominant effect size is mixed: the highest-quality study (an RCT) found a null/neutral effect, while a meta-analysis of 14 trials showed a moderate beneficial reduction in GDM incidence (RR 0.71, 95% CI 0.52–0.96). No consistent dose was reported, and the evidence primarily pertains to pregnant women, including those at high risk or overweight/obese.3 beneficial1 neutral4 studies