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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Best Supplements for Reduced Prevalence of Gestational Diabetes Mellitus

Ranked by research evidence. Compare 6 supplements across 13 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.

Top picks by evidence

  • 1Lactobacillus salivarius UCC118
    Moderate evidence4 studies

    Across 4 studies (3 meta-analyses, 1 review), all reported beneficial moderate-sized effects of probiotic supplementation on reducing gestational diabetes mellitus (GDM) risk, with 2 meta-analyses finding statistically significant reductions. The evidence primarily comes from analyses of multiple probiotic strains in pregnant women, not specifically L. salivarius UCC118.

    Product match
    Metagenics — UltraFlora Integrity
    20 mg · $67.50
  • 2Bifidobacterium longum SP54
    Low evidence4 studies

    Across 4 studies, 3 reported beneficial effects (predominantly moderate-sized) and 1 reported a neutral effect on reducing gestational diabetes mellitus (GDM) incidence. The only statistically significant finding came from a 2024 meta-analysis of 14 RCTs showing a moderate reduction in GDM risk (RR 0.71, p=0.03), while an individual RCT found no significant difference. Most studies did not specify dose or form, and the evidence base is small.

    Product match
    Life Extension — Florassist Probiotic
    · $24.75 · ★4.6 (2,653)
6 supplements
  • ModerateLactobacillus salivarius UCC118Across 4 studies (3 meta-analyses, 1 review), all reported beneficial moderate-sized effects of probiotic supplementation on reducing gestational diabetes mellitus (GDM) risk, with 2 meta-analyses finding statistically significant reductions. The evidence primarily comes from analyses of multiple probiotic strains in pregnant women, not specifically L. salivarius UCC118.4 beneficial4 studies
  • LowBifidobacterium longum SP54Across 4 studies, 3 reported beneficial effects (predominantly moderate-sized) and 1 reported a neutral effect on reducing gestational diabetes mellitus (GDM) incidence. The only statistically significant finding came from a 2024 meta-analysis of 14 RCTs showing a moderate reduction in GDM risk (RR 0.71, p=0.03), while an individual RCT found no significant difference. Most studies did not specify dose or form, and the evidence base is small.3 beneficial1 neutral4 studies
  • Lactobacillus rhamnosus LBV961 beneficial1 neutral2 studies
  • Lactobacillus rhamnosus HN0011 beneficial1 study
  • Bifidobacterium animalis subsp. lactis BB-121 beneficial1 study
  • Vitamin D1 beneficial1 study
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