Best Supplements for Reduced Prevalence of Gestational Diabetes Mellitus
Ranked by research evidence. Compare 6 supplements across 13 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Moderate evidence4 studies
Across 4 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing the prevalence of gestational diabetes mellitus, with effect sizes ranging from small to moderate. Two of four studies found statistically significant risk reductions, with one meta-analysis reporting a 48% lower risk (RR 0.52, p=0.003) and another reporting a 29% lower risk (RR 0.71, p=0.03). Evidence predominantly comes from meta-analyses of probiotic interventions in pregnant women, though the specific dose and duration are not consistently reported.
- Low evidence4 studies
Across 4 studies, 3 reported beneficial effects of *Bifidobacterium longum* SP54 supplementation for reducing gestational diabetes mellitus (GDM) incidence, with a 2024 meta-analysis of 14 RCTs finding a significant moderate reduction (RR: 0.71, 95% CI: 0.52–0.96). However, the highest-quality individual RCT (n=271) found a neutral, non-significant effect (41.9% vs. 40.2%, P=0.78), and dose, duration, and form were not consistently reported across studies. The predominant effect size among beneficial studies was moderate, but the evidence is limited by the small number of available studies.
- ModerateLactobacillus salivarius UCC118Across 4 studies, all reported beneficial effects of Lactobacillus salivarius UCC118 on reducing the prevalence of gestational diabetes mellitus, with effect sizes ranging from small to moderate. Two of four studies found statistically significant risk reductions, with one meta-analysis reporting a 48% lower risk (RR 0.52, p=0.003) and another reporting a 29% lower risk (RR 0.71, p=0.03). Evidence predominantly comes from meta-analyses of probiotic interventions in pregnant women, though the specific dose and duration are not consistently reported.4 beneficial4 studies
- LowBifidobacterium longum SP54Across 4 studies, 3 reported beneficial effects of *Bifidobacterium longum* SP54 supplementation for reducing gestational diabetes mellitus (GDM) incidence, with a 2024 meta-analysis of 14 RCTs finding a significant moderate reduction (RR: 0.71, 95% CI: 0.52–0.96). However, the highest-quality individual RCT (n=271) found a neutral, non-significant effect (41.9% vs. 40.2%, P=0.78), and dose, duration, and form were not consistently reported across studies. The predominant effect size among beneficial studies was moderate, but the evidence is limited by the small number of available studies.3 beneficial1 neutral4 studies