The effects of capsinoids and fermented red pepper paste supplementation on Glycaemic Control: A systematic review and meta-analysis of randomised controlled trials.

2021-09-25
International journal of clinical practice 75(12)
- Mohammad Reza Amini
- Alireza Talebyan
- Nastaran Payandeh
- Fatemeh Sheikhhossein
- Fatemeh Mohtashaminia
- Fatemeh Gholami

PubMed: 34487384
DOI: 10.1111/ijcp.14803

Study Design

Type: Meta-Analysis
Sample size: n = 530
Population: 530 subjects
Methods: Systematic review and meta-analysis of randomised clinical trials

Objective

The present systematic review and meta-analysis were conducted to investigate the effects of capsinoids supplementation on glycaemic control.

Methods

Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomised clinical trials investigating the effect of capsinoids supplementation on glycaemic control were included.

Results

Of 326 citations, eight trials with nine effect sizes that enrolled 530 subjects were included. Capsinoids and red pepper resulted in no significant reduction in glucose (Weighted mean differences (WMD): -0.27 mg/dL; 95% CI: -1.9 to 1.37, P = .75), insulin (WMD: -0.09 µU/mL; 95% CI: -1.76 to 1.57, P = .913), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD: 0.52; 95% CI: -0.29 to 1.32, P = .208) and haemoglobin A1C (HbA1C) (WMD: 0.01%; 95% CI: -0.04 to 0.05, P = .712). Greater effects on glucose were detected in trials performed on both gender, using red pepper, lasted ≥12 weeks, and participants aged >40 years old and recruited greater sample size >50. Insulin and HOMA-IR were reduced by using red pepper.

Conclusion

Overall, these data suggest that capsinoids and red pepper supplementation did not have beneficial effects on glucose, insulin, HbA1C and HOMA-IR but significantly reduce glucose in people older than 40 years.

Research Insights

Red Pepper→Improved Insulin Levels
Insulin (WMD: -0.09 µU/mL; 95% CI: -1.76 to 1.57, P = .913)
Effect
Neutral
Effect size
Small
Red Pepper→Reduced Blood Glucose Levels
Capsinoids and red pepper resulted in no significant reduction in glucose (Weighted mean differences (WMD): -0.27 mg/dL; 95% CI: -1.9 to 1.37, P = .75)
Effect
Neutral
Effect size
Small
Red Pepper→Reduced HOMA-IR
homeostatic model assessment for insulin resistance (HOMA-IR) (WMD: 0.52; 95% CI: -0.29 to 1.32, P = .208)
Effect
Neutral
Effect size
Small
Red Pepper→Reduced Hemoglobin A1c
haemoglobin A1C (HbA1C) (WMD: 0.01%; 95% CI: -0.04 to 0.05, P = .712)
Effect
Neutral
Effect size
Small