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The effects of collagen peptides on exercise-induced gastrointestinal stress: a randomized, controlled trial.

  • 2022-11-12
  • European journal of nutrition 62(2)
    • Guy Taylor
    • Amber Leonard
    • Jonathan C Y Tang
    • Rachel Dunn
    • William D Fraser
    • Nicolina Virgilio
    • Janne Prawitt
    • Emma Stevenson
    • Tom Clifford

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 20
Population
20 volunteers (16 males: VO2max, 53.4 ± 5.9 ml·kg-1)
Methods
Randomized, crossover design; 7 days of CP (10 g/day) or placebo before a 70 min run at 70-90% VO2max
Duration
7 days
Funding
Unclear
  • Rigorous Journal

Purpose

We examined the effects of collagen peptides (CP) supplementation on exercise-induced gastrointestinal (GI) stress.

Methods

In a randomized, crossover design, 20 volunteers (16 males: [Formula: see text]O2max, 53.4 ± 5.9 ml·kg-1) completed 3 trials: a non-exercise rest trial, with no supplement (REST) and then an exercise trial with CP (10 g·day-1) or placebo control (CON) supplements, which were consumed for 7 days prior to, and 45 min before, a 70 min run at 70-90% of [Formula: see text]O2max. Outcome measures included urinary lactulose and rhamnose (L/R), intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), anti-LPS antibody, monocyte-chemoattractant protein-1 (MCP-1), interleukin (IL) 6 and 8, cortisol, alkaline phosphatase (ALP) (measured pre, 10 min post and 2 h post) and subjective GI symptoms.

Results

There were no differences in heart rate, perceived exertion, thermal comfort, or core temperature during exercise in the CP and CON trials (all P > 0.05). I-FABP was higher in CP (2538 ± 1221 pg/ml) and CON (2541 ± 766 pg/ml) vs. REST 2 h post (1893 ± 1941 pg/ml) (both P < 0.05). LPS increased in CON vs. REST 2 h post (+ 71.8 pg/ml; P < 0.05). Anti-LPS antibody decreased in CON and CP vs. REST at post (both P < 0.05). There were no differences in MCP-1, IL-6, and IL-8 between the CP and CON trials (all P > 0.05), and no differences in L/R or GI symptoms between CON and CP (all P > 0.05).

Conclusion

Collagen peptides did not modify exercise-induced changes in inflammation, GI integrity or subjective GI symptoms but LPS was higher in CON 2 h post-exercise and thus future studies may be warranted.

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