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The Effects of Korean Red Ginseng on Biological Aging and Antioxidant Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled Study.

  • 2021-09-02
  • Nutrients 13(9)
    • Tae-Ha Chung
    • Ji-Hye Kim
    • So-Young Seol
    • Yon-Ji Kim
    • Yong-Jae Lee

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 63
Population
Postmenopausal women
Methods
double-blinded, placebo-controlled clinical trial; participants were randomly administered KRG or a placebo; measured mitochondria DNA (mtDNA) copy number, total antioxidant status (TAS), and fatigue severity scale
Blinding
Double-blind
Funding
Unclear
  • Rigorous Journal
Postmenopausal women are vulnerable to aging and oxidative stress due to reduced estrogen. Previous studies have shown that Korean red ginseng (KRG) has beneficial effects on aging and antioxidant capacity. Therefore, we evaluated the effects of KRG on biological aging and antioxidant capacity in postmenopausal women. This study conducted a double-blinded, placebo-controlled clinical trial. The participants were randomly administered KRG or a placebo, and the following metrics were measured: mitochondria DNA (mtDNA) copy number as an indicator of biological aging and, total antioxidant status (TAS) as a marker of antioxidant capacity. Clinical symptoms of fatigue, as measured by the fatigue severity scale, were assessed before and after KRG administration. There were 63 participants, of whom 33 received KRG and 30 received a placebo. The mtDNA copy number (KRG group: 1.58 ± 2.05, placebo group: 0.28 ± 2.36, p = 0.023) and TAS (KRG group: 0.11 ± 0.25 mmol/L, placebo group: -0.04 ± 0.16 mmol/L, p = 0.011) increased and the fatigue severity scale (KRG group: -7 ± 12, placebo group: -1 ± 11, p = 0.033) decreased significantly more in the KRG group than the placebo group. KRG significantly increased the mtDNA copy number, total antioxidant status, and improved symptoms of fatigue in postmenopausal women.

Research Insights

  • Red Ginseng→Reduced Fatigue

    the fatigue severity scale (KRG group: -7 ± 12, placebo group: -1 ± 11, p = 0.033) decreased significantly more in the KRG group than the placebo group.

    Effect
    Beneficial
    Effect size
    Moderate
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