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The effects of pyridoxine (vitamin B6) supplementation in nausea and vomiting during pregnancy: a systematic review and meta-analysis.

  • 2023-01-31
  • Archives of gynecology and obstetrics 308(4)
    • Ranil Jayawardena
    • Shahana Majeed
    • Piumika Sooriyaarachchi
    • Udara Abeywarne
    • Probhodana Ranaweera

Study Design

Type
Meta-Analysis
Population
women suffering from NVP (nausea and vomiting during pregnancy)
Methods
Data were obtained using a stepwise search process using keywords in PubMed, Web of Science, and Scopus for studies published before 1st May 2021; Studies reporting intervention with pyridoxine supplementation alone and/or with other active substances were included; A meta-analysis was performed on the PUQE score and Rhode's score

Purpose

Nausea and vomiting during pregnancy (NVP) are common symptoms in pregnancy. Although no definitive treatment option for NVP, pyridoxine (Vitamin B6) supplementation has been used widely. The present study aims to systematically evaluate the current evidence regarding pyridoxine for the treatment of NVP.

Methods

Data were obtained using a stepwise search process using keywords in the following online medical databases; PubMed®, Web of Science®, and Scopus® for studies published before 1st May 2021. Studies reporting intervention with pyridoxine supplementation alone and/or with other active substances were included. A meta-analysis was performed on the PUQE score and Rhode's score for nausea and vomiting.

Findings

Initial database searching indicated 548 potentially eligible articles, of which 18 studies satisfying the inclusion criteria were selected. Eight studies showed beneficial effects with pyridoxine alone as the supplementation, while six others found that the supplementation of pyridoxine in combination with another active substance had favourable effects. Supplementation of pyridoxine alone as well as combined treatment of pyridoxine with an active ingredient as the intervention significantly improved the symptoms of nausea according to Rhode's score [0.78 [95% CI: 0.26, 1.31; p = 0.003; I2 = 57%, p = 0.10)] and PUQE score [0.75 (95% CI: 0.28, 1.22; p = 0.002; I2 = 0%, p = 0.51)], respectively.

Conclusion

Supplementation of pyridoxine alone as well as with an active ingredient demonstrated beneficial effects for women suffering from NVP.

Research Insights

  • Vitamin B6→Reduced Nausea and Vomiting Severity

    Supplementation of pyridoxine alone as well as combined treatment of pyridoxine with an active ingredient as the intervention significantly improved the symptoms of nausea according to Rhode's score [0.78 [95% CI: 0.26, 1.31; p=0.003; I2=57%, p=0.10)] and PUQE score [0.75 (95% CI: 0.28, 1.22; p=0.002; I2=0%, p=0.51)], respectively.

    Effect
    Beneficial
    Effect size
    Moderate
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