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The effects of rice bran supplementation for management of blood lipids: A GRADE-assessed systematic review, dose-response meta-analysis, and meta-regression of randomized controlled trials.

  • 2023-04-12
  • Systematic reviews 12(1)
    • Zahra Hariri
    • Fatemeh Afzalzade
    • Golbon Sohrab
    • Saeede Saadati
    • Zahra Yari

Study Design

Type
Meta-Analysis
Methods
Systematic review and meta-analysis of RCTs; searched PubMed/Medline, Scopus, ISI Web of Science, Google Scholar up to June 2022; random-effects model, GRADE assessment

Background

We aimed to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to investigate the effects of rice bran supplementation on serum lipid profile levels.

Methods

We searched PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar using related keywords. Published RCTs exploring the effects of rice bran consumption on lipid profile were searched up to June 2022. Evidence certainty was assessed on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. The data were pooled using a random-effects model and reported as weighted mean difference (WMD) and 95% confidence interval (CI) for each outcome.

Results

Meta-analysis of eight RCTs (with 11 effect sizes) showed no significant effect of rice bran supplementation on serum levels of triglyceride (WMD: -11.38 mg/dl; 95% CI: -27.73, 4.96; P = 0.17), total cholesterol (WMD: -0.68 mg/dl; 95% CI: -7.25, 5.88; P = 0.834), low-density lipoprotein cholesterol (WMD: -1.68 mg/dl; 95% CI: -8.46, 5.09; P = 0.627) and high-density lipoprotein cholesterol (WMD: 0.16 mg/dl; 95% CI: -1.52, 1.85; P = 0.848) compared to control group.

Conclusion

Our meta-analysis suggests that rice bran supplementation has no significant effects on serum levels of lipid profile components. However, larger studies with longer durations and improved methodological quality are needed before firm conclusions can be reached.

Research Insights

  • rice bran→Increased HDL Cholesterol Levels

    Meta-analysis of eight RCTs (with 11 effect sizes) showed no significant effect of rice bran supplementation on serum levels of high-density lipoprotein cholesterol (WMD: 0.16 mg/dl; 95% CI: -1.52, 1.85; P = 0.848)

    Effect
    Neutral
    Effect size
    Small
  • rice bran→Reduced Low-Density Lipoprotein Level

    Meta-analysis of eight RCTs (with 11 effect sizes) showed no significant effect of rice bran supplementation on serum levels of low-density lipoprotein cholesterol (WMD: -1.68 mg/dl; 95% CI: -8.46, 5.09; P = 0.627)

    Effect
    Neutral
    Effect size
    Small
  • rice bran→Reduced Total Cholesterol

    Meta-analysis of eight RCTs (with 11 effect sizes) showed no significant effect of rice bran supplementation on serum levels of total cholesterol (WMD: -0.68 mg/dl; 95% CI: -7.25, 5.88; P = 0.834)

    Effect
    Neutral
    Effect size
    Small
  • rice bran→Reduced Triglyceride Levels

    Meta-analysis of eight RCTs (with 11 effect sizes) showed no significant effect of rice bran supplementation on serum levels of triglyceride (WMD: -11.38 mg/dl; 95% CI: -27.73, 4.96; P = 0.17)

    Effect
    Neutral
    Effect size
    Small
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