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The Impact of Flaxseed (Linum usitatissimum L.) Oil Supplementation on Human Health: A Human-Centric Evidence-Graded Approach.

  • 2025-05-25
  • Nutrients 17(11)
    • Ying Nie
    • Yuchen Wang
    • Ju Hui
    • Danqing Shao
    • Ran Chen
    • Qianchun Deng
    • Yashu Chen
    • Xiangyu Wang
    • Dazhou Zhu

Study Design

Type
Review
Methods
13 articles selected as evaluation evidence after applying inclusion/exclusion criteria to 2148 papers retrieved from databases
  • Rigorous Journal

Background

Although flaxseed oil shows potential health benefits, there is a significant gap between preclinical studies (animal/in vitro) and actual effects in humans. The health benefits of flaxseed oil for humans remain unclear.

Objective

This article seeks to precisely identify the health benefits of flaxseed oil by evaluating the scientific evidence from human trials on flaxseed oil.

Methods

According to the gradation method of a human-centric evidence body, 13 articles were ultimately selected as evaluation evidence after applying inclusion/exclusion criteria to the 2148 papers retrieved from scholarly databases.

Results

The evaluation results of the evidence body on inflammatory cytokines, blood pressure, insulin sensitivity, and blood lipid are all B. Additionally, the influences of flaxseed oil consumption on waist circumstance, mood, and cognition are still unclear.

Conclusions

The results reveal that flaxseed oil intervention significantly decreases inflammatory cytokines, blood pressure, and insulin sensitivity, but does not affect blood lipid improvement. Meanwhile, the effect of flaxseed oil intervention on waist circumstance, mood, and cognition need more human trials to determine.

Research Insights

  • Flax→Improved Blood Lipid Profile

    does not affect blood lipid improvement

    Effect
    Neutral
    Effect size
    Small
  • Flax→Improved Cognition

    the influences of flaxseed oil consumption on waist circumstance, mood, and cognition are still unclear

    Effect
    Neutral
    Effect size
    Small
  • Flax→Improved Mood

    the influences of flaxseed oil consumption on waist circumstance, mood, and cognition are still unclear

    Effect
    Neutral
    Effect size
    Small
  • Flax→Reduced Blood Pressure

    flaxseed oil intervention significantly decreases ... blood pressure

    Effect
    Beneficial
    Effect size
    Small
  • Flax→Reduced Insulin Sensitivity

    flaxseed oil intervention significantly decreases ... insulin sensitivity

    Effect
    Harmful
    Effect size
    Small
  • Flax→Reduced Pro-Inflammatory Cytokines

    flaxseed oil intervention significantly decreases inflammatory cytokines

    Effect
    Beneficial
    Effect size
    Small
  • Flax→Reduced Waist Circumference

    the influences of flaxseed oil consumption on waist circumstance, mood, and cognition are still unclear

    Effect
    Neutral
    Effect size
    Small
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