The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats.
- 2019-12
- Nutrition, Metabolism and Cardiovascular Diseases 29(12)
- R. G. S. Cavalcante
- Thatyane Mariano Rodrigues de Albuquerque
- M. O. de Luna Freire
- Georgianna de Araújo Henriques Ferreira
- L. A. Carneiro dos Santos
- M. Magnani
- J. Cruz
- V. Braga
- E. L. de Souza
- J. L. de Brito Alves
- PubMed: 31640890
- DOI: 10.1016/J.NUMECD.2019.08.003
Abstract
Background and aim: High-fat (HF) diet consumption has been associated with gut dysbiosis and increased risk of dyslipidemia, type 2 diabetes mellitus and hypertension. Probiotic administration has been suggested as a safe therapeutic strategy for the treatment of cardiometabolic disorders. This study was designed to assess the effects of probiotic Lactobacillus (L.) fermentum 296, a fruit-derived bacteria strain, against cardiometabolic disorders induced by HF diet.
Methods and results: Male Wistar rats were divided into control diet (CTL); HF diet; and HF diet treated with Lactobacillus fermentum 296 (HF + Lf 296). The L. fermentum 296 strain at 1 × 109 colony forming units (CFU)/ml were daily administered by oral gavage for 4 weeks. The results showed that rats fed with HF diet displayed insulin resistance, reduced Lactobacillus spp. counts in feces, serum lipids, and oxidative profile. Rats fed on HF diet also demonstrated augmented blood pressure associated with sympathetic hyperactivity and impaired baroreflex control. The administration of L. fermentum 296 for 4 weeks recovered fecal Lactobacillus sp. counts and alleviated hyperlipidemia, sympathetic hyperactivity, and reduced systolic blood pressure in HF rats without affecting baroreflex sensibility.
Conclusion: Our results suggest the ability of L. fermentum 296 improve biochemical and cardiovascular parameters altered in cardiometabolic disorders.
Keywords: Dyslipidemia; Hypertension; Lactobacillus fermentum; Microbiota; Probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus fermentum | Improved Insulin Sensitivity | Beneficial | Moderate |
| Lactobacillus fermentum | Reduced Blood Lipid Levels | Beneficial | Moderate |
| Lactobacillus fermentum | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum | Reduced Systolic Blood Pressure | Beneficial | Moderate |
| Lactobacillus fermentum HA-179 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Lactobacillus fermentum HA-179 | Increased Lactobacillus Species Counts | Beneficial | Large |
| Lactobacillus fermentum HA-179 | Reduced Blood Lipid Levels | Beneficial | Moderate |
| Lactobacillus fermentum HA-179 | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum HA-179 | Reduced Systolic Blood Pressure | Beneficial | Moderate |
| Lactobacillus fermentum Lf-33 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Lactobacillus fermentum Lf-33 | Improved Lipid Profile | Beneficial | Moderate |
| Lactobacillus fermentum Lf-33 | Increased Gut Lactobacilli Counts | Beneficial | Moderate |
| Lactobacillus fermentum Lf-33 | Reduced Blood Pressure | Beneficial | Moderate |
| Lactobacillus fermentum Lf-33 | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum LF61 | Improved Lactobacillus Counts | Beneficial | Moderate |
| Lactobacillus fermentum LF61 | Reduced Hyperlipidemia Symptoms | Beneficial | Moderate |
| Lactobacillus fermentum LF61 | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum LF61 | Reduced Systolic Blood Pressure | Beneficial | Moderate |
| Lactobacillus fermentum MAK20L13F | Improved Insulin Sensitivity | Beneficial | Moderate |
| Lactobacillus fermentum MAK20L13F | Improved Lipid Profile | Beneficial | Moderate |
| Lactobacillus fermentum MAK20L13F | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum MAK20L13F | Reduced Systolic Blood Pressure | Beneficial | Moderate |
| Lactobacillus fermentum ME-3 | Improved Gut Microbiota | Beneficial | Moderate |
| Lactobacillus fermentum ME-3 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Lactobacillus fermentum ME-3 | Reduced Serum Lipid Levels | Beneficial | Moderate |
| Lactobacillus fermentum ME-3 | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum ME-3 | Reduced Systolic Blood Pressure | Beneficial | Moderate |
| Lactobacillus fermentum UALf-32 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Lactobacillus fermentum UALf-32 | Improved Lactobacillus Counts | Beneficial | Moderate |
| Lactobacillus fermentum UALf-32 | Reduced Blood Lipid Levels | Beneficial | Moderate |
| Lactobacillus fermentum UALf-32 | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum UALf-32 | Reduced Systolic Blood Pressure | Beneficial | Moderate |
| Lactobacillus fermentum VPro 14 | Improved Insulin Sensitivity | Beneficial | Moderate |
| Lactobacillus fermentum VPro 14 | Increased Faecal Lactobacillus Spp. Counts | Beneficial | Moderate |
| Lactobacillus fermentum VPro 14 | Reduced Blood Lipid Levels | Beneficial | Moderate |
| Lactobacillus fermentum VPro 14 | Reduced Sympathetic Hyperactivity | Beneficial | Large |
| Lactobacillus fermentum VPro 14 | Reduced Systolic Blood Pressure | Beneficial | Moderate |