The role of probiotics in vaginal health.

2022-07-28
Frontiers in cellular and infection microbiology 12
- Zhaojun Mei
- Dandan Li

PubMed: 35967876
DOI: 10.3389/fcimb.2022.963868

Study Design

Type: Review
Methods: We review the research progress of probiotics represented by Lactobacillus in gynecological diseases such as human papilloma virus (HPV) infection, bacterial vaginosis (BV) and Genitourinary Syndrome of Menopause (GSM)

Probiotics have been widely used in the treatment of intestinal diseases, but the effect of probiotics on female reproductive tract health is still controversial. Lactobacillus is the most abundant microorganism in the vagina, which is related to the vaginal mucosal barrier. Lactobacillus adheres to the vaginal epithelium and can competitively antagonize the colonization of pathogens. The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H₂O₂), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer. We review the research progress of probiotics represented by Lactobacillus in gynecological diseases such as human papilloma virus (HPV) infection, bacterial vaginosis (BV) and Genitourinary Syndrome of Menopause (GSM), so as to provide basis for further exerting the role of probiotics in women's health.

Research Insights

Lactobacillus crispatus LBV 88→Improved Vaginal Health
We review the research progress of probiotics represented by Lactobacillus in gynecological diseases such as human papilloma virus (HPV) infection, bacterial vaginosis (BV) and Genitourinary Syndrome of Menopause (GSM), so as to provide basis for further exerting the role of probiotics in women's health.
Effect
Beneficial
Effect size
Moderate
Lactobacillus crispatus LBV 88→Improved Vaginal Microbiota
The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer.
Effect
Beneficial
Effect size
Moderate
Lactobacillus crispatus LBV 88→Reduced Vaginal Colonization of Pathogenic Bacteria
Lactobacillus adheres to the vaginal epithelium and can competitively antagonize the colonization of pathogens.
Effect
Beneficial
Effect size
Moderate
Lactobacillus gasseri LBV 150N→Improved Vaginal Microbiota Balance
The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment
Effect
Beneficial
Effect size
Moderate
Lactobacillus jensenii LBV 116→Improved Immune Function
Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer.
Effect
Beneficial
Effect size
Small
Lactobacillus jensenii LBV 116→Improved Vaginal Microbiota
The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer.
Effect
Beneficial
Effect size
Moderate
Lactobacillus jensenii LBV 116→Reduced Cancer Progression
Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer.
Effect
Beneficial
Effect size
Small
Lactobacillus rhamnosus LBV96→Enhanced Vaginal Immune Defense
Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer.
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus LBV96→Improved Vaginal Microbiota Balance
The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus LBV96→Reduced Pathogen Colonization
Lactobacillus adheres to the vaginal epithelium and can competitively antagonize the colonization of pathogens.
Effect
Beneficial
Effect size
Moderate
Lactobacillus rhamnosus LBV96→Reduced Pathogen Growth
The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms.
Effect
Beneficial
Effect size
Moderate