Lactobacillus jensenii LBV 116 and Improved Vaginal Microbiota

Research synthesisModerate evidenceMixed effect size4 studies · 4 beneficial · 0 neutral · 0 harmful

Across 4 studies, all reported beneficial effects on vaginal microbiota, with the highest-quality evidence (a meta-analysis) showing a statistically significant moderate-sized reduction in Nugent score. The overall effect sizes were mixed (small to moderate). No consistent dose or form was reported across studies.

Studied populations: Women with vaginal dysbiosis (including bacterial vaginosis, intermediate Nugent score), postmenopausal breast cancer patients on chemotherapy, pregnant women with herpes, and male-to-female transsexual women.

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. Additionally, the studies used mixed Lactobacillus strains rather than specifically L. jensenii LBV 116; direct evidence for this specific strain is lacking.

Generated May 12, 2026

4 of 4 papers

Impact of oral administration of four Lactobacillus strains on Nugent score - systematic review and meta-analysis.
- 2019-05-28
- Meta-Analysis · n = 36
- Beneficial microbes 10(5)
- - M de Vrese
  - C Laue
  - E Papazova
  - L Petricevic
  - J Schrezenmeir
- PubMed: 31012733
- DOI: 10.3920/bm2018.0129
1 Insight on
- Improved Vaginal Microbiota
- High evidence
- Rigorous Journal
The meta-analysis of these trials showed a significant reduction of Nugent score by probiotics compared to placebo... This meta-analysis indicates that the oral intake of the pertinent Lactobacillus strains improves the microbial pattern in vaginal dysbiosis.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study.
- 2022-03-11
- RCT · n = 22
- Breast care (Basel, Switzerland) 12(5)
- - Julian Marschalek
  - Alex Farr
  - Marie-Louise Marschalek
  - Konrad J Domig
  - Wolfgang Kneifel
  - Christian F Singer
  - Herbert Kiss
  - Ljubomir Petricevic
- PubMed: 29234255
- DOI: 10.1159/000478994
1 Insight on
- Improved Vaginal Microbiota
- High evidence
We observed a positive influence on the vaginal microbiota in 7/11 (63%) women in the intervention group, and 4/11 (36%) women in the control group. There was a shift in Nugent score towards normal microbiota levels in the intervention group
Effect
Beneficial
Effect size
Small
Vaginal and tumor microbiomes in gynecological cancer (Review).
- 2023-03-03
- Review
- Oncology letters 25(4)
- - Mengzhen Han
  - Na Wang
  - Wenjie Han
  - Meng Ban
  - Tao Sun
  - Junnan Xu
- PubMed: 36936020
- DOI: 10.3892/ol.2023.13739
2 Insights on
- Improved Vaginal Microbiota
- Low evidence
Lactobacilli participate in the formation of a healthy vaginal microenvironment as the first line of defense against pathogen invasion; a dysbiotic vaginal microenvironment loses its original protective function
Effect
Beneficial
Effect size
Small
The role of probiotics in vaginal health.
- 2022-07-28
- Review
- Frontiers in cellular and infection microbiology 12
- - Zhaojun Mei
  - Dandan Li
- PubMed: 35967876
- DOI: 10.3389/fcimb.2022.963868
9 Insights on
- Improved Vaginal Microbiota
- Low evidence
The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer.
Effect
Beneficial
Effect size
Moderate

Lactobacillus jensenii LBV 116 and Improved Vaginal Microbiota

Impact of oral administration of four Lactobacillus strains on Nugent score - systematic review and meta-analysis.

Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study.

Vaginal and tumor microbiomes in gynecological cancer (Review).

The role of probiotics in vaginal health.