Lactobacillus jensenii LBV 116 and Improved Vaginal Microbiota

• Impact of oral administration of four Lactobacillus strains on Nugent score - systematic review and meta-analysis.

  • 2019-05-28
  • Meta-Analysis · n = 36
  • Beneficial microbes 10(5)
  • • M de Vrese
    • C Laue
    • E Papazova
    • L Petricevic
    • J Schrezenmeir

  • PubMed: 31012733
  • DOI: 10.3920/bm2018.0129

  1 Insight on

  • Improved Vaginal Microbiota

  • High evidence
  • Rigorous Journal

  The meta-analysis of these trials showed a significant reduction of Nugent score by probiotics compared to placebo... This meta-analysis indicates that the oral intake of the pertinent Lactobacillus strains improves the microbial pattern in vaginal dysbiosis.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study.

  • 2022-03-11
  • RCT · n = 22
  • Breast care (Basel, Switzerland) 12(5)
  • • Julian Marschalek
    • Alex Farr
    • Marie-Louise Marschalek
    • Konrad J Domig
    • Wolfgang Kneifel
    • Christian F Singer
    • Herbert Kiss
    • Ljubomir Petricevic

  • PubMed: 29234255
  • DOI: 10.1159/000478994

  1 Insight on

  • Improved Vaginal Microbiota

  • High evidence

  We observed a positive influence on the vaginal microbiota in 7/11 (63%) women in the intervention group, and 4/11 (36%) women in the control group. There was a shift in Nugent score towards normal microbiota levels in the intervention group

  Effect

  Beneficial

  Effect size

  Small

• Vaginal and tumor microbiomes in gynecological cancer (Review).

  • 2023-03-03
  • Review
  • Oncology letters 25(4)
  • • Mengzhen Han
    • Na Wang
    • Wenjie Han
    • Meng Ban
    • Tao Sun
    • Junnan Xu

  • PubMed: 36936020
  • DOI: 10.3892/ol.2023.13739

  2 Insights on

  • Improved Vaginal Microbiota

  • Low evidence

  Lactobacilli participate in the formation of a healthy vaginal microenvironment as the first line of defense against pathogen invasion; a dysbiotic vaginal microenvironment loses its original protective function

  Effect

  Beneficial

  Effect size

  Small

• The role of probiotics in vaginal health.

  • 2022-07-28
  • Review
  • Frontiers in cellular and infection microbiology 12
  • • Zhaojun Mei
    • Dandan Li

  • PubMed: 35967876
  • DOI: 10.3389/fcimb.2022.963868

  9 Insights on

  • Improved Vaginal Microbiota

  • Low evidence

  The factors produced by Lactobacillus, such as bacteriocin and hydrogen peroxide (H2O2), can inhibit the growth of pathogenic microorganisms and maintain the low pH environment of the vagina. Probiotics play an important role in maintaining the stability of vaginal microenvironment, improving immune defense and blocking the progression of cervical cancer.

  Effect

  Beneficial

  Effect size

  Moderate