Research synthesisModerate evidenceModerate effect4 studies · 4 beneficial · 0 neutral · 0 harmful
Across 4 studies, all reported beneficial effects of Lactobacillus jensenii LBV 116 on vaginal microbiota, with effect sizes ranging from small to moderate. The strongest evidence comes from a meta-analysis of 4 RCTs showing a significant reduction in Nugent score, indicating improved microbial patterns in women with vaginal dysbiosis. The predominant effect size is moderate, and the most-studied population includes postmenopausal breast cancer patients on chemotherapy and women with bacterial vaginosis.
- Studied populations: Women with vaginal dysbiosis, postmenopausal breast cancer patients receiving chemotherapy, pregnant women with herpes virus infection, and male-to-female transsexual women with neovagina.
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Evidence base is small (only 4 studies) — conclusions should be considered preliminary. Only 1 of 4 studies reported a statistically significant finding, suggesting the effect may be smaller than the predominant direction indicates. Many studies lacked dose, form, and duration data, limiting dose-response conclusions.
Generated Jun 11, 2026