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Which Protein-Based Dietary Supplements Most Effectively Enhance Fat-Free Mass and Strength Gains in Healthy Adults Undergoing Resistance Training? A Network Meta-Analysis.

  • 2026-01
  • Translational sports medicine 2026(1)
    • Marcos D M Drummond
    • Ronaldo A D Silva
    • Nelson Carvas Junior
    • Miércio S Melo
    • Matheus H L Ferreira

Study Design

Type
Review
Sample size
n = 4,755
Population
healthy adults engaged in strength training
Methods
network meta-analysis of randomized controlled trials evaluating different protein supplements combined with strength training
Funding
Unclear

Background

Various protein-based dietary supplements are widely used by individuals engaged in strength training to optimize gains in muscle strength and fat-free mass. However, gaps remain in the scientific literature regarding a comprehensive comparison-particularly the effectiveness of different types of supplemented proteins in healthy adults. This systematic review and network meta-analysis aimed to compare the effectiveness of protein-based dietary supplements, combined with strength training, on increasing muscle strength and fat-free mass in healthy adults.

Methods

A network meta-analysis was conducted using randomized controlled trials evaluating different protein supplements combined with strength training. The outcomes assessed were muscle strength (primary) and fat-free mass (secondary). The search was performed in PubMed, Scopus, and Embase up to May 2024, with no restrictions on language or publication date.

Results

A total of 78 studies were included, comprising 4755 participants across two outcomes and involving 13 types of protein supplements, plus placebo and control groups. Compared to placebo, for strength, collagen was the most effective supplement (SMD = 0.41; 95% CI: 0.09 to 0.73; p = 0.0125; SUCRA 88.05%), followed by whey protein (SMD = 0.15; 95% CI: 0.03 to 0.27; p = 0.0145; SUCRA 64.34%). The other supplements showed no statistically significant differences compared to placebo (p > 0.05). For fat-free mass, results were similar. Collagen showed a statistically superior effect (SMD = 0.94; 95% CI: 0.48 to 1.40; p < 0.0001; SUCRA 98.92%), followed by whey protein (SMD = 0.16; 95% CI: 0.05 to 0.28; p = 0.0051; SUCRA 60.23%). Other supplements showed no statistically significant differences (p > 0.05).

Conclusion

Collagen and whey protein are the only protein supplements effective in enhancing strength training effects. Moreover, collagen shows a superior effect compared to whey protein for both outcomes.

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