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Evidence-Based Supplement Research
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Vitamin B1 and Improved Left Ventricular Ejection Fraction

Research synthesisVery low evidenceSmall effect3 studies · 1 beneficial · 2 neutral · 0 harmful

Across 3 studies, 1 reported a beneficial small effect of Vitamin B1 (as part of a multi-nutrient supplement) on left ventricular ejection fraction, while 2 studies found no significant effect (neutral). The most-studied dose was 50–100 mg/day in clinical populations with heart conditions or undergoing cardiac surgery. The median study duration was short (15 days), so longer-term effects remain unclear. Evidence is small and preliminary.

  • Effective dose range: 50–100 mg/day
  • Studied populations: children with heart disease (on diuretics), patients undergoing elective cardiac surgery, general heart failure patients

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Two of three studies found no significant effect, and the single beneficial study tested a combination supplement (thiamine, ubiquinol, D-ribose, L-arginine), so the independent effect of Vitamin B1 is unclear. Study durations were very short (1–28 days), limiting applicability to chronic supplementation.

Generated Jun 13, 2026
Doses used in studies
  • mg/day: 50–100 (median 75, IQR 62.5–87.5) — 2 studies
Time to effect
Median: 2.1 weeks · IQR 8 days–3 weeks · Range 1 day–4 weeks — Reported in 2 of 3 studies
3 of 3 papers
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