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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B1 and Reduced Fatigue

Doses used in studies

mg/day: 300 (median 300, IQR 300–300) — 1 study

Time to effect

Median: 4 weeks · IQR 4 weeks–4 weeks · Range 4 weeks–4 weeks — Reported in 1 of 2 studies

2 of 2 papers

Effects of B vitamins and magnesium on fatigue, disease activity and quality of life in inflammatory bowel disease.
- 2026-04-21
- RCT · n = 98
- Scientific reports 16(1)
- - Elmira Ramezani
  - Palle Bager
  - Kimia Torabinasab
  - Nasser Ebrahimi Daryani
  - Mehdi Azizmohammad Looha
  - Mohammad Masoumvand
  - Mohammad Taher
  - Masoud Ashadzadeh
  - Mohammadreza Vafa
- PubMed: 42010310
- DOI: 10.1038/s41598-026-49880-7
4 Insights on
- Reduced Fatigue
- High evidence
- Rigorous Journal
- Clinical
and Section 2 (β = - 5.19; p < 0.001)
Effect
Beneficial
Effect size
Small
Significant
Yes
PHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.
- 2026-01-09
- Review · n = 935
- Arquivos de gastroenterologia 62
- - Tayane Morais
  - Genalva Couto
  - Raquel Rocha
  - Genoile Santana
- PubMed: 41538673
- DOI: 10.1590/s0004-2803.24612025-081
1 Insight on
- Reduced Fatigue
- High evidence
- Clinical
High doses of oral thiamine reduce fatigue, but studies using a dose of 300 mg/day of thiamine have not shown the same effect.
Effect
Beneficial
Effect size
Moderate
Dose
high doses of oral thiamine (but 300 mg/day not shown same effect)