Vitamin B12 and Improved Memory Function

• The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review.

  • 2026-04-08
  • Review
  • Frontiers in nutrition 13
  • • Hailong Zhang
    • Chenyang Liu
    • Xingxing Yuan
    • Hongna Yin

  • PubMed: 42027570
  • DOI: 10.3389/fnut.2026.1818913

  2 Insights on

  • Improved Memory Function

  • Low evidence

  certain combinations like omega-3 fatty acids paired with carotenoids, B vitamins (folate/B12), and probiotics show promise, particularly for improving memory and reducing inflammation

  Effect

  Beneficial

  Effect size

  Small

  Significant

  No

• Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.

  • 2024-11-09
  • Review
  • Cureus 16(11)
  • • Hayat Alzahrani

  • PubMed: 39655146
  • DOI: 10.7759/cureus.73350

  2 Insights on

  • Improved Memory Function

  • Low evidence
  • Clinical

  For cognitive memory function, eight of the nine included studies were analyzed, showing an average standardized mean difference of -0.03 (95% confidence interval (CI): -0.07 to 0.01), indicating no significant effect of vitamin B12 supplementation (p = 0.1801) and no significant heterogeneity.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No