Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.
- 2024-11-09
- Review
- Cureus 16(11)
- Hayat Alzahrani
- PubMed: 39655146
- DOI: 10.7759/cureus.73350
- Low evidence
- Clinical
For cognitive memory function, eight of the nine included studies were analyzed, showing an average standardized mean difference of -0.03 (95% confidence interval (CI): -0.07 to 0.01), indicating no significant effect of vitamin B12 supplementation (p = 0.1801) and no significant heterogeneity.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No