Vitamin B12 and Reduced Depression Symptoms

Time to effect

Median: 5.6 months · IQR 5.6 months–5.6 months · Range 5.6 months–5.6 months — Reported in 1 of 2 studies

2 of 2 papers

Association of serum homocysteine, folate, and vitamin B12 and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial.

2023-05-01
RCT · n = 77
Multiple sclerosis and related disorders 75
- Farnoosh Shemirani
- Tyler J Titcomb
- Solange M Saxby
- Patrick Ten Eyck
- Linda M Rubenstein
- Karin F Hoth
- Linda G Snetselaar
- Terry L Wahls

PubMed: 37148578
DOI: 10.1016/j.msard.2023.104743

3 Insights on

Reduced Depression Symptoms

High evidence
Clinical

Changes in serum levels of homocysteine and vitamin B12 were not associated with and did not mediate changes in HADS depression, anxiety, MHI total and four subscales scores (p > 0.05).

Effect: Neutral
Effect size: Small
Significant: No
Dose: not specified (part of supplement regimen)

Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis.

2024-11-09
Review
Cureus 16(11)
- Hayat Alzahrani

PubMed: 39655146
DOI: 10.7759/cureus.73350

2 Insights on

Reduced Depression Symptoms

Low evidence
Clinical

Regarding depressive symptoms, three of the nine included studies were analyzed, yielding an average standardized mean difference of -0.01 (95% CI: -0.0773 to 0.0525), also showing no significant effect (p = 0.708).

Effect: Neutral
Effect size: Small
Significant: No