Vitamin B12 and Reduced Homocysteine Level

• Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis.

  • 2026-01-30
  • Meta-Analysis · n = 539
  • Annals of medicine 58(1)
  • • Liping Guo
    • Xiangfen Shi
    • Gaobiao Wang
    • Wenchao Han
    • Rui Ding
    • Shihao Wang
    • Dongdong Yuan

  • PubMed: 41615824
  • DOI: 10.1080/07853890.2026.2622208

  4 Insights on

  • Reduced Homocysteine Level

  • High evidence
  • Clinical

  Combined B-vitamin supplementation significantly reduced serum Hcy levels [mean difference: -2.36; 95% CI: (-3.09 to -1.62); p < 0.01]

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes