Vitamin B12 and Reduced Homocysteine Level

• A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels.

  • 2023-07-26
  • Meta-Analysis · n = 1,625
  • Nutrition reviews 82(6)
  • • Mohammad Hassan Sohouli
    • Faisal Almuqayyid
    • Aya Alfardous Alazm
    • Fateme Ziamanesh
    • Elma Izze da Silva Magalhães
    • Seyedeh Elaheh Bagheri
    • Bianca Rodrigues de Oliveira
    • Mahmoud Alfardous Alazm
    • Abdul Rahman Adi
    • Sara Alomar
    • Ahmed Abu-Zaid

  • PubMed: 37495210
  • DOI: 10.1093/nutrit/nuad091

  1 Insight on

  • Reduced Homocysteine Level

  • High evidence
  • Clinical

  Hcy levels were significantly lower after B12 supplementation compared with the control group (pooled weighted mean difference, -4.15 μmol/L; 95% confidence interval, -4.86, -3.45; P < 0.001)

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  greater than 500 µg/d (for dose subgroup)

• Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis.

  • 2026-01-30
  • Meta-Analysis · n = 539
  • Annals of medicine 58(1)
  • • Liping Guo
    • Xiangfen Shi
    • Gaobiao Wang
    • Wenchao Han
    • Rui Ding
    • Shihao Wang
    • Dongdong Yuan

  • PubMed: 41615824
  • DOI: 10.1080/07853890.2026.2622208

  4 Insights on

  • Reduced Homocysteine Level

  • High evidence
  • Clinical

  Combined B-vitamin supplementation significantly reduced serum Hcy levels [mean difference: -2.36; 95% CI: (-3.09 to -1.62); p < 0.01]

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes