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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B2 and Reduced Migraine Duration

Doses used in studies

mg/day: 400 (median 400, IQR 400–400) — 1 study

Time to effect

Median: 3 months · IQR 3 months–3 months · Range 3 months–3 months — Reported in 1 of 2 studies

2 of 2 papers

Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis.
- 2021-03-29
- Meta-Analysis · n = 673
- Nutritional neuroscience 25(9)
- - Yu-Shiue Chen
  - Huan-Fang Lee
  - Ching-Hsuan Tsai
  - Yu-Yun Hsu
  - Ching-Ju Fang
  - Chen-Ju Chen
  - Yu-Hsin Hung
  - Fang-Wen Hu
- PubMed: 33779525
- DOI: 10.1080/1028415x.2021.1904542
3 Insights on
- Reduced Migraine Duration
- High evidence
Vitamin B2 supplementation significantly decreased ... duration (p = .003, I² = 0)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
400 mg/day for three months
The effect of riboflavin on the mean attack frequency, severity, and duration of migraine headaches: A systematic review and dose-response meta-analysis of clinical trials.
- 2026-01
- Review
- Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 31(1)
- - Sepide Amini
  - Zahra Heidari
  - Cain C T Clark
  - Mohammad Bagherniya
- PubMed: 41769676
- DOI: 10.4103/jrms.jrms_547_24
2 Insights on
- Reduced Migraine Duration
- Low evidence
Riboflavin had a significant effect on ... duration of migraine (WMD: -1.36, 95% CI: -2.69 to -0.03; I² = 90.4%, P < 0.001)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
up to 400 mg/day