Best Supplements for Reduced Migraine Duration
Ranked by research evidence. Compare 6 supplements across 9 papers from the biomedical literature, with effect direction, evidence strength, and dose range for each.
Top picks by evidence
- Low evidence3 studies
Across 3 studies, 2 reported beneficial effects of vitamin B2 (riboflavin) on reducing migraine duration, with effect sizes ranging from moderate in a 2022 meta-analysis (400 mg/day, 90 days) to mixed in a 2026 review (up to 400 mg/day), while a large 2024 pediatric meta-analysis found no significant benefit. The most-studied dose is 400 mg/day, and effects were typically observed over 90 days. Overall, evidence is mixed, with beneficial findings limited to adult populations and no effect seen in pediatric patients.
Dose: 400 mg/day
6 supplements
- LowVitamin B2Across 3 studies, 2 reported beneficial effects of vitamin B2 (riboflavin) on reducing migraine duration, with effect sizes ranging from moderate in a 2022 meta-analysis (400 mg/day, 90 days) to mixed in a 2026 review (up to 400 mg/day), while a large 2024 pediatric meta-analysis found no significant benefit. The most-studied dose is 400 mg/day, and effects were typically observed over 90 days. Overall, evidence is mixed, with beneficial findings limited to adult populations and no effect seen in pediatric patients. · Dose: 400 mg/day2 beneficial1 neutral3 studies