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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B2 and Reduced Pain

Doses used in studies

mg/day: 400–1,200 (median 800, IQR 600–1,000) — 2 studies

Time to effect

Median: 10.7 weeks · IQR 9.6 weeks–11.8 weeks · Range 8.6 weeks–3 months — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis.
- 2021-03-29
- Meta-Analysis · n = 673
- Nutritional neuroscience 25(9)
- - Yu-Shiue Chen
  - Huan-Fang Lee
  - Ching-Hsuan Tsai
  - Yu-Yun Hsu
  - Ching-Ju Fang
  - Chen-Ju Chen
  - Yu-Hsin Hung
  - Fang-Wen Hu
- PubMed: 33779525
- DOI: 10.1080/1028415x.2021.1904542
3 Insights on
- Reduced Pain
- High evidence
Vitamin B2 supplementation significantly decreased ... pain score (p = .015, I² = 84%)
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
400 mg/day for three months
Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study.
- 2023-06-23
- RCT
- Acta bio-medica : Atenei Parmensis 94(S2)
- - Marco D'Orio
  - Rocco De Vitis
  - Giuseppe Taccardo
  - Lorenzo Rocchi
  - Federico Ferrari
  - Andrea Perna
  - Marco Passiatore
- PubMed: 37366197
- DOI: 10.23750/abm.v94is2.12513
5 Insights on
- Reduced Pain
- High evidence
- Clinical
as well as BCTQ symptoms subscale, and the pain.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
600 mg twice daily