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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Vitamin B3 and Reduced Depression Symptoms

Doses used in studies

mg single-dose: 100 (median 100, IQR 100–100) — 1 study
mg/day: 100 (median 100, IQR 100–100) — 1 study

Time to effect

Median: 6.8 months · IQR 4.1 months–9.5 months · Range 6 weeks–12.2 months — Reported in 2 of 2 studies

2 of 2 papers

Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression: A Randomized Clinical Trial.
- 2026-05-15
- RCT · n = 35
- JAMA network open 9(5)
- - Hampus Yngwe
  - Pontus Plavén-Sigray
  - Carl Johan Ekman
  - Eva Henje
  - Anders Berglund
  - Mikael Tiger
  - Maria Beckman
  - Johan Lundberg
- PubMed: 42138922
- DOI: 10.1001/jamanetworkopen.2026.12589
2 Insights on
- Reduced Depression Symptoms
- High evidence
- Rigorous Journal
- Clinical
For MADRS-S, the psilocybin group had a significantly greater reduction beginning at day 2 (mean difference, -9.58; 95% CI, -16.05 to -3.11; P = .004), with group differences persisting through day 102 (mean difference, -6.60; 95% CI, -13.01 to -0.19; P = .04)
Effect
Neutral
Effect size
Small
Significant
No
Dose
100 mg single dose
Psilocybin-assisted psychotherapy for depression and anxiety associated with life threatening illness: A phase 2b randomized controlled trial.
- 2025-09
- RCT · n = 18
- General hospital psychiatry 96
- - Margaret L Ross
  - Ravi Iyer
  - Martin L Williams
  - Mark Boughey
  - Clare O'Callaghan
  - Richard Hiscock
  - Justin Dwyer
- PubMed: 40858059
- DOI: 10.1016/j.genhosppsych.2025.08.001
2 Insights on
- Reduced Depression Symptoms
- High evidence
- Clinical
Psilocybin produced significantly greater reductions in HADS depression ... compared to placebo. Benefits were sustained at 26 weeks.
Effect
Neutral
Effect size
Small
Significant
No
Dose
100 mg