Vitamin B3 and Reduced HIF-1α mRNA Expression

Doses used in studies

mg/day: 500 (median 500, IQR 500–500) — 1 study

Time to effect

Median: 7 days · IQR 7 days–7 days · Range 7 days–7 days — Reported in 1 of 1 study

1 of 1 paper

Correlation of changes in HIF-1α and p53 expressions with vitamin B3 deficiency in skin cancer patients.

2019-10
RCT
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 154(5)
- Ting Liu
- Hao Yang
- Yunzhu Mou
- Hao Zhang

PubMed: 29064206
DOI: 10.23736/s0392-0488.17.05775-3

4 Insights on

Reduced HIF-1α mRNA Expression

High evidence
Clinical

The protein and mRNA expression levels of HIF-1α and p53 in tissues of skin cancer patients were significantly decreased at 1 week after the oral administration of vitamin B3 compared with those before the oral administration of vitamin B3 (P<0.05)

Effect: Beneficial
Effect size: Moderate
Significant: Yes
Dose: 500 mg/day